Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.51 |
| ▸ | TNKS | O95271 | 6/20 | 0.47 |
| ▸ | TNKS2 | Q9H2K2 | 6/20 | 0.47 |
| ▸ | GCGR | P47871 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 4/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.43 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | SCD | O00767 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 2/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9693499 | 0.83 | ALDH1A1 (0.58) | TNKSTNKS2GCGRNPBWR1KDM4E | |
| SCHEMBL28563694 | 0.80 | KDM4E (0.47) | TNKSTNKS2PARP1KDM4ENPC1 | |
| SCHEMBL22191835 | 0.75 | NPC1 (0.53) | TNKSTNKS2NPBWR1NPC1ALDH1A1 | |
| SCHEMBL4468341 | 0.75 | PRKCI (0.47) | HDAC6TNKSTNKS2GCGRPARP1 | |
| SCHEMBL13864512 | 0.74 | ALDH1A1 (0.66) | HDAC6TNKSTNKS2GCGRTRPV1 | |
| SCHEMBL4465876 | 0.74 | HDAC6 (0.61) | HDAC6TNKSTNKS2GCGRPARP1 | |
| SCHEMBL3286054 | 0.72 | HDAC6 (0.60) | HDAC6TNKSTNKS2GCGRPARP1 | |
| SCHEMBL4190003 | 0.71 | TRPV1 (0.56) | HDAC6GCGRTRPV1NPBWR1AURKA | |
| SCHEMBL21705583 | 0.71 | HDAC6 (0.66) | HDAC6TNKSTNKS2GCGRPARP1 | |
| SCHEMBL31027907 | 0.71 | HDAC6 (0.66) | HDAC6TNKSTNKS2GCGRPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7538113-B2 | 4-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor | WYETH (US) | 2009-05-26 | — | — | US | disclosed |
| US-7538113-B2 | 4-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor | WYETH (US) | 2009-05-26 | — | — | US | disclosed |
| US-7538113-B2 | 4-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor | WYETH (US) | 2009-05-26 | — | — | US | disclosed |
| US-20060189618-A1 | 4-Substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor | WYETH (US) | 2006-08-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060189618-A1 | 4-Substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor | GNRHR, LHCGR, FSHR | HDAC6 1529/4885TNKS 2751/4885TNKS2 3420/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.