Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.72 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | SLC18A3 | Q16572 | 5/20 | 0.56 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.49 |
| ▸ | L3MBTL3 | Q96JM7 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1003630 | 0.80 | LTA4H (0.58) | LTA4HCYP2D6CYP2C19SLC18A3SIGMAR1 | |
| SCHEMBL28702035 | 0.80 | CYP2D6 (0.93) | CYP2D6CYP2C19SLC18A3GRIN2BL3MBTL3 | |
| SCHEMBL13660519 | 0.80 | SLC18A3 (0.57) | LTA4HCYP2D6CYP2C19SLC18A3SIGMAR1 | |
| SCHEMBL447356 | 0.79 | SLC18A3 (0.50) | LTA4HCYP2D6CYP2C19SLC18A3SIGMAR1 | |
| SCHEMBL15184744 | 0.78 | CYP2D6 (0.83) | CYP2D6CYP2C19SLC18A3GRIN2BL3MBTL3 | |
| SCHEMBL13498019 | 0.77 | CYP2D6 (1.00) | CYP2D6CYP2C19SLC18A3GRIN2BSIGMAR1 | |
| SCHEMBL5007409 | 0.77 | AKR1C3 (0.51) | LTA4HCYP2D6CYP2C19CYP1A2CYP2C9 | |
| SCHEMBL444560 | 0.77 | AKR1C3 (0.56) | LTA4HCYP2D6CYP2C19SLC18A3GRIN2B | |
| SCHEMBL3630710 | 0.76 | LTA4H (0.47) | LTA4HCYP2D6CYP2C19SLC18A3GRIN2B | |
| SCHEMBL5000672 | 0.74 | LTA4H (0.53) | LTA4HCYP2D6CYP2C19SLC18A3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120065188-A1 | SUBSTITUTED HETEROCYCLIC DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS | PFIZER INC | 2012-03-15 | — | — | US | disclosed |
| US-20110092480-A1 | Substituted Heterocyclic Derivatives and Their Pharmaceutical Use and Compositions | PFIZER INC. | 2011-04-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120065188-A1 | SUBSTITUTED HETEROCYCLIC DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS | XDH, CYP2D6, F12 | LTA4H 2266/4885CYP2D6 2/4885CYP2C19 13/4885 |
| US-20110092480-A1 | Substituted Heterocyclic Derivatives and Their Pharmaceutical Use and Compositions | XDH, CYP2D6, F12 | LTA4H 2266/4885CYP2D6 2/4885CYP2C19 13/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.