Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HCAR1 | Q9BXC0 | 4/20 | 0.38 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.35 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.35 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CASP6 | P55212 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4498723 | 0.95 | ALDH1A1 (0.44) | ALDH1A1KDM4ESMN1; SMN2HCAR1PDE7A | |
| SCHEMBL4498921 | 0.90 | ALDH1A1 (0.48) | ALDH1A1KDM4ESMN1; SMN2HCAR1PDE7A | |
| SCHEMBL4465222 | 0.80 | MAPT (0.43) | ALDH1A1KDM4ESMN1; SMN2GRIN2DGRIN3B | |
| SCHEMBL4471023 | 0.80 | MEN1 (0.44) | ALDH1A1KDM4EHPGDKMT2AMAPT | |
| SCHEMBL4454520 | 0.77 | MAPT (0.47) | ALDH1A1KDM4EHPGDKMT2AMAPT | |
| SCHEMBL15330466 | 0.74 | ALDH1A1 (0.44) | ALDH1A1KDM4ESMN1; SMN2HCAR1PDE7A | |
| SCHEMBL4492126 | 0.74 | MAPT (0.47) | ALDH1A1KDM4ESMN1; SMN2GRIN2DGRIN3B | |
| SCHEMBL4566658 | 0.74 | CA12 (0.38) | ALDH1A1KDM4ESMN1; SMN2HPGDKMT2A | |
| SCHEMBL4501815 | 0.73 | MEN1 (0.47) | ALDH1A1KDM4EHPGDKMT2AMAPT | |
| SCHEMBL4458183 | 0.72 | GRIN2D (0.38) | KDM4EGRIN2DGRIN3BGRIN1GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010534-A1 | THIOXANTHINE DERIVATIVES AND THEIR USE AS INHIBITORS OF MPO | AstraZeneca AB (SE) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007120097-A1 | THIOXANTHINE DERIVATIVES AND THEIR USE AS INHIBITORS OF MPO | ASTRAZENECA AB (SE) | 2007-10-25 | — | — | WO | disclosed |