Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.37 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.37 |
| ▸ | ITGAV | P06756 | 1/20 | 0.37 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.35 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4471855 | 1.00 | ALDH1A1 (0.45) | ALDH1A1HTTKDM4ERAB9AMAPT | |
| SCHEMBL6284069 | 0.95 | ALDH1A1 (0.43) | ALDH1A1HTTKDM4ERAB9AMAPT | |
| SCHEMBL6284060 | 0.95 | ALDH1A1 (0.43) | ALDH1A1HTTKDM4ERAB9AMAPT | |
| SCHEMBL6284064 | 0.95 | ALDH1A1 (0.43) | ALDH1A1HTTKDM4ERAB9AMAPT | |
| SCHEMBL21612277 | 0.76 | MAPT (0.41) | ALDH1A1HTTRAB9AMAPTHPGD | |
| SCHEMBL21612276 | 0.76 | MAPT (0.41) | ALDH1A1HTTRAB9AMAPTHPGD | |
| SCHEMBL21612280 | 0.76 | MAPT (0.41) | ALDH1A1HTTRAB9AMAPTHPGD | |
| SCHEMBL21612440 | 0.76 | MAPT (0.41) | ALDH1A1HTTRAB9AMAPTHPGD | |
| SCHEMBL9154714 | 0.74 | ALDH1A1 (0.53) | ALDH1A1HTTKDM4ERAB9AMAPT | |
| SCHEMBL9154722 | 0.74 | ALDH1A1 (0.53) | ALDH1A1HTTKDM4ERAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7576118-B2 | Asymmetric hydrogenation process | MERCK & CO., INC. (US) | 2009-08-18 | — | — | US | disclosed |
| US-7576118-B2 | Asymmetric hydrogenation process | MERCK & CO., INC. (US) | 2009-08-18 | — | — | US | disclosed |
| US-7576118-B2 | Asymmetric hydrogenation process | MERCK & CO., INC. (US) | 2009-08-18 | — | — | US | disclosed |
| EP-1737820-B1 | ASYMMETRIC HYDROGENATION PROCESS USEFUL FOR THE PREPARATION OF CYCLOALKANOINDOLE DERIVATIVES | MERCK & CO INC (US) | 2008-01-16 | — | — | EP | disclosed |
| EP-1737820-B1 | ASYMMETRIC HYDROGENATION PROCESS USEFUL FOR THE PREPARATION OF CYCLOALKANOINDOLE DERIVATIVES | MERCK & CO INC (US) | 2008-01-16 | — | — | EP | disclosed |
| EP-1737820-A1 | ASYMMETRIC HYDROGENATION PROCESS USEFUL FOR THE PREPARATION OF CYCLOALKANOINDOLE DERIVATIVES | Merck & Co., Inc. (US) | 2007-01-03 | — | — | EP | disclosed |
| WO-2005097745-A1 | ASYMMETRIC HYDROGENATION PROCESS USEFUL FOR THE PREPARATION OF CYCLOALKANOINDOLE DERIVATIVES | MERCK & CO., INC. (US) | 2005-10-20 | — | — | WO | disclosed |
| US-20050222428-A1 | Asymmetric hydrogenation process | MERCK SHARP & DOHME CORP. | 2005-10-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050222428-A1 | Asymmetric hydrogenation process | HRH2, HTR5A, OPRD1 | ALDH1A1 2480/4885HTT 1100/4885KDM4E 4612/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.