Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 2/20 | 0.34 |
| ▸ | HTR2C | P28335 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.30 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL931175 | 0.85 | HTR1A (0.34) | MAPTHTR1AHTR2CLMNAHTT | |
| SCHEMBL4664286 | 0.73 | ESR1 (0.34) | MAPTLMNAHTTESR1ESR2 | |
| SCHEMBL3973501 | 0.72 | KDM4E (0.34) | MAPTESR1ESR2 | |
| SCHEMBL421071 | 0.70 | ALDH1A1 (0.38) | MAPTHTT | |
| SCHEMBL930153 | 0.69 | HSP90AA1 (0.34) | MAPTLMNAHTTPDE3BPDE3A | |
| SCHEMBL10345296 | 0.69 | ALDH1A1 (0.37) | MAPTLMNAHTT | |
| SCHEMBL2596695 | 0.68 | SMN1; SMN2 (0.37) | MAPTLMNAHTT | |
| SCHEMBL15940226 | 0.67 | MAP3K11 (0.39) | MAPTLMNAHTT | |
| SCHEMBL931391 | 0.67 | HTR1A (0.38) | MAPTHTR1AHTR2CLMNA | |
| SCHEMBL8931406 | 0.67 | RPA1 (0.42) | MAPTLMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2034996-A2 | TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY | Synta Pharmaceuticals Corporation (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007139955-A2 | TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY | SYNTA PHARMACEUTICALS CORP. (US) | 2007-12-06 | — | — | WO | disclosed |