SCHEMBL447210

SCHEMBL447210

Nc1ccc(CCOC[C@H]2O[C@@H](n3cnc4c(N)ncnc43)[C@H](O)[C@@H]2O)cc1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA1 P30542 5/20 0.62
SMN1; SMN2 Q16637 3/20 0.62
ADORA3 P0DMS8 2/20 0.62
ADORA2A P29274 2/20 0.62
ADORA2B P29275 2/20 0.62
MAPK1 P28482 2/20 0.62
DPP4 P27487 1/20 0.62
MEN1 O00255 1/20 0.62
SLC28A1 O00337 1/20 0.62
MAP3K7 O43318 1/20 0.62
SLC28A2 O43868 1/20 0.62
GAPDH P04406 1/20 0.62
STAT6 P42226 1/20 0.62
PI4KA P42356 1/20 0.62
KMT2A Q03164 1/20 0.62
PI4K2B Q8TCG2 1/20 0.62
DOT1L Q8TEK3 1/20 0.62
SLC29A1 Q99808 1/20 0.62
PI4K2A Q9BTU6 1/20 0.62
SLC28A3 Q9HAS3 1/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1434130 0.92 ADORA1 (0.67) ADORA1SMN1; SMN2ADORA3ADORA2AADORA2B
SCHEMBL932846 0.90 ADORA1 (0.65) ADORA1SMN1; SMN2ADORA3ADORA2AADORA2B
SCHEMBL13269023 0.89 ADORA1 (0.58) ADORA1SMN1; SMN2ADORA3ADORA2AADORA2B
SCHEMBL8328542 0.89 ADORA1 (0.74) ADORA1SMN1; SMN2ADORA3ADORA2AADORA2B
SCHEMBL7860970 0.87 ADORA1 (0.57) ADORA1SMN1; SMN2ADORA3ADORA2AADORA2B
SCHEMBL13268940 0.87 ADORA2A (0.57) ADORA1SMN1; SMN2ADORA3ADORA2AADORA2B
SCHEMBL13269089 0.86 ADORA2A (0.64) ADORA1SMN1; SMN2ADORA3ADORA2AADORA2B
SCHEMBL2270709 0.86 ADORA1 (0.73) ADORA1SMN1; SMN2ADORA3ADORA2AADORA2B
SCHEMBL6828798 0.86 ADORA1 (0.70) ADORA1SMN1; SMN2ADORA3ADORA2AADORA2B
SCHEMBL13269099 0.85 ADORA2A (0.57) ADORA1SMN1; SMN2ADORA3ADORA2AADORA2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 157 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230201240-A1 TREATMENT OF ADVANCED METASTATIC CANCER CAN-FITE BIOPHARMA LTD. (IL) 2023-06-29 US claimed
EP-3906034-A1 AN A3 ADENOSINE RECEPTOR LIGAND FOR USE FOR ACHIEVING A FAT LOSS EFFECT Can-Fite Biopharma Ltd. (IL) 2021-11-10 EP claimed
US-20210069227-A1 A3 ADENOSINE RECEPTOR LIGAND FOR MANAGING CYTOKINE RELEASE SYNDROME CAN-FITE BIOPHARMA LTD (IL) 2021-03-11 US claimed
EP-3681538-A1 A3 ADENOSINE RECEPTOR LIGAND FOR MANAGING CYTOKINE RELEASE SYNDROME Can-Fite Biopharma Ltd. (IL) 2020-07-22 EP claimed
WO-2020141535-A1 AN A3 ADENOSINE RECEPTOR LIGAND FOR USE FOR ACHIEVING A FAT LOSS EFFECT CAN-FITE BIOPHARMA LTD. (IL) 2020-07-09 WO claimed
EP-3530273-A2 A3 ADENOSINE RECEPTOR LIGANDS FOR USE IN TREATMENT OF A SEXUAL DYSFUNCTION Can-Fite Biopharma Ltd. (IL) 2019-08-28 EP claimed
WO-2019053723-A1 A3 ADENOSINE RECEPTOR LIGAND FOR MANAGING CYTOKINE RELEASE SYNDROME CAN-FITE BIOPHARMA LTD (IL) 2019-03-21 WO claimed
EP-3380104-A1 AN A3 ADENOSINE RECEPTOR LIGAND FOR USE IN TREATING ECTOPIC FAT ACCUMULATION Can-Fite Biopharma Ltd. (IL) 2018-10-03 EP claimed
WO-2017090036-A1 AN A3 ADENOSINE RECEPTOR LIGAND FOR USE IN TREATING ECTOPIC FAT ACCUMULATION CAN-FITE BIOPHARMA LTD. (IL) 2017-06-01 WO claimed
US-9549943-B2 A3 adenosine receptor ligands for use in treatment of a sexual dysfunction CAN-FITE BIOPHARMA LTD. (IL) 2017-01-24 US claimed
EP-1383515-B1 ACTIVATION OF NATURAL KILLER CELLS BY ADENOSINE A3 RECEPTOR AGONISTS CAN FITE BIOPHARMA LTD (IL) 2004-12-15 EP claimed
US-20040204481-A1 Activation of natural killer cells by adenosine A3 receptor agonists CAN-FITE BIOPHARMA LTD. (IL) 2004-10-14 US claimed
WO-2004088312-A2 FLUORESCENTLY TAGGED LIGANDS UNIVERSITY OF NOTTINGHAM (GB) 2004-10-14 WO claimed
JP-2004520404-A 2004-07-08 JP claimed
EP-1383515-A1 ACTIVATION OF NATURAL KILLER CELLS BY ADENOSINE A3 RECEPTOR AGONISTS Can-Fite Biopharma Ltd. (IL) 2004-01-28 EP claimed
EP-1363644-A2 MODULATION OF GSK-3BETA ACTIVITY AND ITS DIFFERENT USES Can-Fite Biopharma Ltd. (IL) 2003-11-26 EP claimed
US-20020165197-A1 Administering adenosine receptor ligand CAN-FITE BIOPHARMA LTD. (IL) 2002-11-07 US claimed
WO-2002083152-A1 ACTIVATION OF NATURAL KILLER CELLS BY ADENOSINE A3 RECEPTOR AGONISTS CAN-FITE BIOPHARMA LTD. (IL) 2002-10-24 WO claimed
WO-2002066020-A2 MODULATION OF GSK-3BETA ACTIVITY AND ITS DIFFERENT USES CAN-FITE BIOPHARMA LTD. (IL) 2002-08-29 WO claimed
US-20020115635-A1 Modulation of GSK-3beta activity and its different uses CAN-FITE TECHNOLOGIES LTD. (IL) 2002-08-22 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230201240-A1 TREATMENT OF ADVANCED METASTATIC CANCER ADORA3, ADORA2A, ADORA1 ADORA1 3/4885SMN1; SMN2 4028/4885ADORA3 1/4885
US-20040204481-A1 Activation of natural killer cells by adenosine A3 receptor agonists ADORA3, ADORA2A, ADORA1 ADORA1 3/4885SMN1; SMN2 3939/4885ADORA3 1/4885
US-20210069227-A1 A3 ADENOSINE RECEPTOR LIGAND FOR MANAGING CYTOKINE RELEASE SYNDROME ADORA3, ADORA2A, IL1RN ADORA1 5/4885SMN1; SMN2 4203/4885ADORA3 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.