Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 5/20 | 0.57 |
| ▸ | P2RY1 | P47900 | 4/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | P2RY2 | P41231 | 3/20 | 0.57 |
| ▸ | SRC | P12931 | 2/20 | 0.57 |
| ▸ | DNPH1 | O43598 | 1/20 | 0.57 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.57 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.57 |
| ▸ | LDHA | P00338 | 1/20 | 0.57 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.57 |
| ▸ | FBP1 | P09467 | 1/20 | 0.57 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.57 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.57 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.57 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.57 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.57 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.57 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.57 |
| ▸ | P2RY11 | Q96G91 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8664327 | 0.91 | ADORA1 (0.58) | ADORA1P2RY1SMN1; SMN2P2RY2SRC | |
| SCHEMBL13269023 | 0.88 | ADORA1 (0.58) | ADORA1P2RY1SMN1; SMN2P2RY2SRC | |
| SCHEMBL447210 | 0.87 | ADORA1 (0.62) | ADORA1P2RY1SMN1; SMN2P2RY2SRC | |
| SCHEMBL1434130 | 0.86 | ADORA1 (0.67) | ADORA1P2RY1SMN1; SMN2P2RY2SRC | |
| SCHEMBL8328542 | 0.84 | ADORA1 (0.74) | ADORA1P2RY1SMN1; SMN2P2RY2SRC | |
| SCHEMBL13268940 | 0.84 | ADORA2A (0.57) | ADORA1P2RY1SMN1; SMN2P2RY2SRC | |
| SCHEMBL13269099 | 0.84 | ADORA2A (0.57) | ADORA1P2RY1SMN1; SMN2P2RY2SRC | |
| SCHEMBL2270709 | 0.81 | ADORA1 (0.73) | ADORA1P2RY1SMN1; SMN2P2RY2SRC | |
| SCHEMBL6828798 | 0.81 | ADORA1 (0.70) | ADORA1P2RY1SMN1; SMN2P2RY2SRC | |
| SCHEMBL2534140 | 0.80 | EHMT1 (0.70) | ADORA1P2RY1SMN1; SMN2P2RY2SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6303619-B1 | BLOCKING VASOCONSTRICTIVE RESPONSE INDUCED THROUGH ADENOSINE ACTIVATION OF THE A.SUB.3 ADENOSINE RECEPTOR SUBTYPE, COMPRISING ADMINISTERING XANTHINE DERIVATIVE TO MAMMAL | UNIVERSITY OF VIRGINIA | 2001-10-16 | — | — | US | disclosed |
| US-5817760-A | MAMMALIAN CELL MEMBRANES | MERCK & CO., INC. (US) | 1998-10-06 | — | — | US | disclosed |
| EP-0689405-A4 | METHODS FOR PROTECTING TISSUES AND ORGANS FROM ISCHEMIC DAMAGE | GENSIA INC (US) | 1996-09-11 | — | — | EP | disclosed |
| EP-0689405-A1 | METHODS FOR PROTECTING TISSUES AND ORGANS FROM ISCHEMIC DAMAGE | GENSIA, INC. (US) | 1996-01-03 | — | — | EP | disclosed |
| WO-1995011681-A1 | HUMAN ADENOSINE RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1995-05-04 | — | — | WO | disclosed |
| WO-1994021195-A1 | METHODS FOR PROTECTING TISSUES AND ORGANS FROM ISCHEMIC DAMAGE | GENSIA, INC. (US) | 1994-09-29 | — | — | WO | disclosed |