Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDR2 | Q16832 | 1/20 | 0.54 |
| ▸ | RAF1 | P04049 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | LCLAT1 | Q6UWP7 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4474065 | 0.92 | DDR2 (0.55) | DDR2RAF1KMT2AMEN1KDR | |
| SCHEMBL4476005 | 0.90 | RAF1 (0.45) | DDR2RAF1KMT2AMEN1KDR | |
| SCHEMBL4463483 | 0.89 | RAF1 (0.64) | DDR2RAF1KDRRETBRAF | |
| SCHEMBL4463605 | 0.89 | LMNA (0.46) | DDR2RAF1KDRNPC1RET | |
| SCHEMBL9102033 | 0.88 | LCLAT1 (0.42) | DDR2KMT2AMEN1KDRNPC1 | |
| SCHEMBL4480264 | 0.88 | KDR (0.43) | DDR2RAF1KDRGRM5RET | |
| SCHEMBL4463604 | 0.86 | RAF1 (0.51) | DDR2RAF1KDRRETBRAF | |
| SCHEMBL4470556 | 0.85 | RAF1 (0.49) | DDR2RAF1KMT2AMEN1KDR | |
| SCHEMBL5420554 | 0.83 | DDR2 (0.61) | DDR2RAF1KMT2AMEN1KDR | |
| SCHEMBL4485728 | 0.83 | RET (0.43) | DDR2RAF1KDRGRM5RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7598274-B2 | N-methyl-4-{4-[5-(4-chloro-3-trifluoromethylphenylcarbamoyl)-1H-pyrrol-3-yl]-phenoxy}pyridine-2-carboxamide; Raf kinases inhibitors | MERCK PATENT GMBH (DE) | 2009-10-06 | — | — | US | claimed |