Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDR2 | Q16832 | 2/20 | 0.55 |
| ▸ | RAF1 | P04049 | 5/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | KDR | P35968 | 7/20 | 0.45 |
| ▸ | BRAF | P15056 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 2/20 | 0.43 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.43 |
| ▸ | HIPK4 | Q8NE63 | 2/20 | 0.43 |
| ▸ | CCNC | P24863 | 2/20 | 0.43 |
| ▸ | CDK8 | P49336 | 2/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | CIT | O14578 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | MUSK | O15146 | 1/20 | 0.43 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
| ▸ | MLNR | O43193 | 1/20 | 0.43 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4473374 | 0.92 | DDR2 (0.54) | DDR2RAF1MEN1KMT2AKDR | |
| SCHEMBL4469831 | 0.88 | RAF1 (0.71) | DDR2RAF1MEN1KMT2AKDR | |
| SCHEMBL4479105 | 0.88 | RAF1 (0.46) | DDR2RAF1MEN1KMT2AKDR | |
| SCHEMBL9103507 | 0.88 | KMT2A (0.43) | DDR2RAF1MEN1KMT2AKDR | |
| SCHEMBL4467015 | 0.86 | KDR (0.59) | DDR2RAF1MEN1KMT2AKDR | |
| SCHEMBL4476005 | 0.82 | RAF1 (0.45) | DDR2RAF1MEN1KMT2AKDR | |
| SCHEMBL1662323 | 0.81 | RAF1 (0.75) | DDR2RAF1MEN1KMT2AKDR | |
| SCHEMBL4463483 | 0.80 | RAF1 (0.64) | DDR2RAF1KDRBRAFMAPT | |
| SCHEMBL4463605 | 0.80 | LMNA (0.46) | DDR2RAF1KDRBRAFMAPT | |
| SCHEMBL9102033 | 0.80 | LCLAT1 (0.42) | DDR2MEN1KMT2AKDRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1685125-B1 | Pyrrole derivatives useful for the treatment of proliferative diseases | MERCK PATENT GMBH (DE) | 2012-06-06 | — | — | EP | claimed |
| US-7598274-B2 | N-methyl-4-{4-[5-(4-chloro-3-trifluoromethylphenylcarbamoyl)-1H-pyrrol-3-yl]-phenoxy}pyridine-2-carboxamide; Raf kinases inhibitors | MERCK PATENT GMBH (DE) | 2009-10-06 | — | — | US | claimed |