Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 1.00 |
| ▸ | CCR1 | P32246 | 4/20 | 0.60 |
| ▸ | CCR8 | P51685 | 4/20 | 0.60 |
| ▸ | MAPT | P10636 | 4/20 | 0.60 |
| ▸ | CCR5 | P51681 | 3/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | HTT | P42858 | 3/20 | 0.60 |
| ▸ | MMP2 | P08253 | 2/20 | 0.60 |
| ▸ | TSHR | P16473 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.60 |
| ▸ | GMNN | O75496 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | MMP9 | P14780 | 1/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.60 |
| ▸ | MMP8 | P22894 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8404537 | 0.81 | LMNA (0.68) | LMNACCR1CCR8MAPTCCR5 | |
| SCHEMBL29989596 | 0.78 | LMNA (0.65) | LMNACCR1CCR8MAPTCCR5 | |
| SCHEMBL9374479 | 0.78 | LMNA (0.65) | LMNACCR1CCR8MAPTCCR5 | |
| SCHEMBL18434875 | 0.78 | LMNA (0.64) | LMNACCR1CCR8MAPTCCR5 | |
| SCHEMBL23954442 | 0.78 | LMNA (0.63) | LMNACCR1CCR8MAPTCCR5 | |
| SCHEMBL623096 | 0.78 | LMNA (0.63) | LMNACCR1CCR8MAPTCCR5 | |
| SCHEMBL5546382 | 0.78 | LMNA (0.63) | LMNACCR1CCR8MAPTCCR5 | |
| SCHEMBL10911576 | 0.78 | LMNA (0.63) | LMNACCR1CCR8MAPTCCR5 | |
| SCHEMBL22026143 | 0.78 | LMNA (0.63) | LMNACCR1CCR8MAPTCCR5 | |
| SCHEMBL3070366 | 0.78 | LMNA (0.63) | LMNACCR1CCR8MAPTCCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102649786-B | Preparation method for 2, 4-diamino-5-(8-dimethylamino-7-methyl-5-quinolyl Methyl)-2, 4-(1H and 3H) pyrimidine | ZHENGZHOU FUYUAN ANIMAL PHARMACEUTICAL CO LTD | 2014-08-27 | — | — | CN | claimed |
| CN-102649786-A | Preparation method for 2, 4-diamino-5-(8-dimethylamino-7-methyl-5-quinolyl Methyl)-2, 4-(1H and 3H) pyrimidine | ZHENGZHOU FUYUAN ANIMAL PHARMACEUTICAL CO LTD | 2012-08-29 | — | — | CN | claimed |
| EP-4735453-A1 | KRAS MODULATING COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2026-05-06 | — | — | EP | disclosed |
| US-20250059208-A1 | KRAS MODULATING COMPOUNDS | GILEAD SCIENCES, INC. | 2025-02-20 | — | — | US | disclosed |
| WO-2025006704-A1 | KRAS MODULATING COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2025-01-02 | — | — | WO | disclosed |
| CN-117865886-B | N- (quinoline-8-yl) quinoline-8-sulfonamide compound and application thereof | 中国药科大学 | 2024-05-10 | — | — | CN | disclosed |
| CN-117865886-A | N- (quinoline-8-yl) quinoline-8-sulfonamide compound and application thereof | 中国药科大学 | 2024-04-12 | — | — | CN | disclosed |
| US-20220081412-A1 | QUINOLINYL-PYRAZINE-CARBOXAMIDE COMPOUNDS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2022-03-17 | — | — | US | disclosed |
| US-20210277003-A1 | OGA INHIBITOR COMPOUNDS | JANSSEN PHARMACEUTICA NV (BE) | 2021-09-09 | — | — | US | disclosed |
| CN-104903321-B | Three ring benzimidazoles are substituted as kinase inhibitor | 赛尔维他股份公司 | 2017-10-24 | — | — | CN | disclosed |
| US-9745299-B2 | Substituted tricyclic benzimidazoles as kinase inhibitors | SELVITA SA (PL) | 2017-08-29 | — | — | US | disclosed |
| US-7585859-B2 | PDE4B inhibitors and uses therefor | PLEXXIKON, INC. (US) | 2009-09-08 | — | — | US | disclosed |
| US-7470794-B2 | Preparation and use of ortho-sulfonamido aryl hydroxamic acids as matrix metalloproteinase inhibitors | WYETH (US) | 2008-12-30 | — | — | US | disclosed |
| EP-1993154-A1 | Electron transporting materials and organic light-emitting devices therewith | Yamagata Promotional Organization for Industrial Technology (JP) | 2008-11-19 | — | — | EP | disclosed |
| US-20060041006-A1 | PDE4B inhibitors and uses therefor | PLEXXIKON, INC. | 2006-02-23 | — | — | US | disclosed |
| US-4761475-A | 2,4-diaminopyrimidines substituted with heterobicyclomethyl radicals at the 5 position useful as antibacterials | SCHERING-PLOUGH ANIMAL HEALTH CORPORATION | 1988-08-02 | — | — | US | disclosed |
| US-4587342-A | 2,4-diamino-(substituted-benzopyran(quinolyl,isoquinoly)methyl)pyrimidines useful as antibacterials | SCHERING-PLOUGH ANIMAL HEALTH CORPORATION | 1986-05-06 | — | — | US | disclosed |
| EP-0051879-B1 | SUBSTITUTED PYRIMIDINES, THEIR SYNTHESIS AND COMPOSITIONS CONTAINING THEM, THEIR USE IN MEDICINE AND INTERMEDIATES FOR MAKING THEM | THE WELLCOME FOUNDATION LIMITED (GB) | 1986-02-05 | — | — | EP | disclosed |
| EP-0051879-A2 | Substituted pyrimidines, their synthesis and compositions containing them, their use in medicine and intermediates for making them | THE WELLCOME FOUNDATION LIMITED (GB) | 1982-05-19 | — | — | EP | disclosed |
| US-3956420-A | CPOLYOLEFIN COMPOSITION FOR ELECTRICAL INSULATIONFERROCENE, 8-SUBSTITUTED QUINOLINE | DAINICHI-NIPPON CABLES, LTD. (JA) | 1976-05-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220081412-A1 | QUINOLINYL-PYRAZINE-CARBOXAMIDE COMPOUNDS AND USES THEREOF | HMGB3, HCCS, ACACA | LMNA 1772/4885CCR1 477/4885CCR8 1379/4885 |
| US-20210277003-A1 | OGA INHIBITOR COMPOUNDS | OGA, OGT, GRN | LMNA 848/4885CCR1 4729/4885CCR8 4812/4885 |
| US-20060041006-A1 | PDE4B inhibitors and uses therefor | PDE4B, PDE7B, PDE4A | LMNA 2349/4885CCR1 4273/4885CCR8 3580/4885 |
| US-20250059208-A1 | KRAS MODULATING COMPOUNDS | KRAS, NRAS, HRAS | LMNA 3815/4885CCR1 2969/4885CCR8 2748/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.