Xanthine

Xanthine

SCHEMBL447388

N.O=c1[nH]c(=O)c2[nH]cnc2[nH]1

nearest known ligand 0.96

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GDA Q9Y2T3 3/20 0.96
ACHE P22303 1/20 0.96
ABL1 P00519 1/20 0.47
RIN1 Q13671 1/20 0.47
ADORA2B P29275 6/20 0.46
ADORA2A P29274 3/20 0.46
ALDH1A1 P00352 2/20 0.45
PNP P00491 1/20 0.43
TDP1 Q9NUW8 1/20 0.42
PDE4A P27815 2/20 0.42
PDE4B Q07343 2/20 0.42
PDE4C Q08493 2/20 0.42
PDE4D Q08499 2/20 0.42
ADORA3 P0DMS8 5/20 0.40
USP2 O75604 1/20 0.39
TP53 P04637 1/20 0.39
HPGD P15428 1/20 0.39
PTGS1 P23219 1/20 0.39
MAPK3 P27361 1/20 0.39
XDH P47989 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Xanthine SCHEMBL2352524 0.98 GDA (1.00) GDAACHEABL1RIN1ADORA2B
Xanthine SCHEMBL4965 0.98 GDA (1.00) GDAACHEABL1RIN1ADORA2B
Xanthine SCHEMBL29669592 0.98 GDA (1.00) GDAACHEABL1RIN1ADORA2B
Xanthine SCHEMBL7044227 0.96 GDA (0.96) GDAACHEABL1RIN1ADORA2B
Xanthine SCHEMBL31152020 0.96 GDA (0.96) GDAACHEABL1RIN1ADORA2B
Xanthine SCHEMBL6783299 0.96 GDA (0.96) GDAACHEABL1RIN1ADORA2B
Xanthine SCHEMBL2454001 0.96 GDA (0.96) GDAACHEABL1RIN1ADORA2B
Xanthine SCHEMBL7044230 0.96 GDA (0.96) GDAACHEABL1RIN1ADORA2B
Xanthine SCHEMBL31488667 0.96 GDA (0.96) GDAACHEABL1RIN1ADORA2B
Xanthine SCHEMBL7849418 0.96 GDA (0.96) GDAACHEABL1RIN1ADORA2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 410 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119817601-A Composite microbial agent and application thereof in improving saline-alkali stress resistance of crops 山东农大肥业科技股份有限公司 2025-04-15 CN claimed
US-20230285556-A1 METHODS AND COMPOSITIONS FOR TREATING CANCER OMEROS CORPORATION 2023-09-14 US claimed
WO-2023039578-A1 METHODS AND COMPOSITIONS FOR TREATING CANCER OMEROS CORPORATION (US) 2023-03-16 WO claimed
EP-3900712-A1 GPCR HETEROMER INHIBITORS AND USES THEREOF GPCR Therapeutics, Inc. (KR) 2021-10-27 EP claimed
EP-3727371-A1 GPCR HETEROMER INHIBITORS AND USES THEREOF GPCR Therapeutics, Inc. (KR) 2020-10-28 EP claimed
US-20190209594-A1 PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF CHEMORESISTANT ACUTE MYELOID LEUKEMIA (AML) UNIVERSITE PAUL SABATIER TOULOUSE III (FR) 2019-07-11 US claimed
EP-3452092-A1 PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF CHEMORESISTANT ACUTE MYELOID LEUKEMIA (AML) INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) 2019-03-13 EP claimed
WO-2017191300-A1 PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF CHEMORESISTANT ACUTE MYELOID LEUKEMIA (AML) INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) 2017-11-09 WO claimed
EP-2507241-A1 METHANOCARBA ADENOSINE DERIVATIVES AND DENDRIMER CONJUGATES THEREOF The U.S.A. As Represented By The Secretary, Department Of Health And Human Services (US) 2012-10-10 EP claimed
US-20110189255-A1 DRUG-ELUTING STENTS FOR ADENOSINE RECEPTOR MODULATION PURDUE RESEARCH FOUNDATION 2011-08-04 US claimed
EP-1014995-A1 COMPOSITIONS AND METHODS FOR PREVENTING RESTENOSIS FOLLOWING REVASCULARIZATION PROCEDURES Discovery Therapeutics, Inc. (US) 2000-07-05 EP claimed
US-6060481-A Method for improving insulin sensitivity using an adenosine receptor antagonist THE PENN STATE RESEARCH FOUNDATION (US) 2000-05-09 US claimed
EP-0970696-A1 Combination of loop diuretics with adenosine A1-receptor antagonists KYOWA HAKKO KOGYO CO., LTD. (JP) 2000-01-12 EP claimed
EP-0814810-A4 ADENOSINE AS A POSITIVE INOTROP IN THE COMPROMISED HEART UNIV MASSACHUSETTS MEDICAL (US) 1999-06-09 EP claimed
WO-1998057651-A1 COMPOSITIONS AND METHODS FOR PREVENTING RESTENOSIS FOLLOWING REVASCULARIZATION PROCEDURES DISCOVERY THERAPEUTICS, INC. (US) 1998-12-23 WO claimed
EP-0814810-A1 ADENOSINE AS A POSITIVE INOTROP IN THE COMPROMISED HEART UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER (US) 1998-01-07 EP claimed
US-5629298-A INCREASING CONTRACTILE PERFORMANCE, ADENOSINE TRANSPORT INHIBITORS USED AS POTENTIATORS UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER (US) 1997-05-13 US claimed
EP-0755254-A1 PREVENTION AND TREATMENT OF ISCHEMIA-REPERFUSION AND ENDOTOXIN-RELATED INJURY USING ADENOSINE AND PURINO RECEPTOR ANTAGONISTS THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 1997-01-29 EP claimed
WO-1996028163-A1 ADENOSINE AS A POSITIVE INOTROP IN THE COMPROMISED HEART UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER (US) 1996-09-19 WO claimed
WO-1995026728-A1 PREVENTION AND TREATMENT OF ISCHEMIA-REPERFUSION AND ENDOTOXIN-RELATED INJURY USING ADENOSINE AND PURINO RECEPTOR ANTAGONISTS THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 1995-10-12 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230285556-A1 METHODS AND COMPOSITIONS FOR TREATING CANCER TP53, CD4, MCL1 GDA 1187/4885ACHE 3357/4885ABL1 1033/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.