Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | LIN28A | Q9H9Z2 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | HRH1 | P35367 | 2/20 | 0.43 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CXCR4 | P61073 | 4/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Zinc Ion SCHEMBL30268708 | 0.85 | SMN1; SMN2 (0.79) | MAPTSMN1; SMN2LIN28ATDP1HRH1 | |
| SCHEMBL138261 | 0.83 | SMN1; SMN2 (0.83) | MAPTSMN1; SMN2LIN28ATDP1HRH1 | |
| SCHEMBL5052519 | 0.83 | TDP1 (0.51) | MAPTSMN1; SMN2LIN28ATDP1KMT2A | |
| SCHEMBL5050820 | 0.83 | MAPT (0.51) | MAPTSMN1; SMN2LIN28ATDP1KCNA5 | |
| SCHEMBL13955402 | 0.82 | TDP1 (0.51) | MAPTSMN1; SMN2LIN28ATDP1KCNA5 | |
| SCHEMBL31533187 | 0.81 | SMN1; SMN2 (0.79) | MAPTSMN1; SMN2LIN28ATDP1HRH1 | |
| Hydrochloric Acid SCHEMBL9905725 | 0.81 | SMN1; SMN2 (0.79) | MAPTSMN1; SMN2LIN28ATDP1HRH1 | |
| SCHEMBL31533189 | 0.81 | SMN1; SMN2 (0.79) | MAPTSMN1; SMN2LIN28ATDP1HRH1 | |
| SCHEMBL14357958 | 0.81 | MAPT (0.79) | MAPTSMN1; SMN2LIN28ATDP1HRH1 | |
| SCHEMBL31171174 | 0.81 | SMN1; SMN2 (0.79) | MAPTSMN1; SMN2LIN28ATDP1HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7488820-B2 | Naphthofluorescein-based metal sensors, and methods of making and using the same | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2009-02-10 | — | — | US | disclosed |
| US-20050186555-A1 | Naphthofluorescein-based metal sensors, and methods of making and using the same | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2005-08-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050186555-A1 | Naphthofluorescein-based metal sensors, and methods of making and using the same | NCF1, NDUFV2, NQO1 | MAPT 2751/4885SMN1; SMN2 4014/4885LIN28A 2886/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.