Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 8/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3443301 | 0.80 | HSD11B1 (0.36) | HSD11B1HDAC4AVPR1AALDH1A1 | |
| SCHEMBL4477197 | 0.78 | HDAC4 (0.38) | HSD11B1HDAC4ALDH1A1 | |
| SCHEMBL31045722 | 0.72 | HDAC4 (0.49) | HSD11B1HDAC4CHEK1KCNH2AVPR1A | |
| SCHEMBL31045917 | 0.72 | HDAC4 (0.49) | HSD11B1HDAC4CHEK1KCNH2AVPR1A | |
| Hydrochloric Acid SCHEMBL4000831 | 0.72 | HDAC4 (0.52) | HSD11B1HDAC4CHEK1KCNH2AVPR1A | |
| SCHEMBL15113219 | 0.70 | HDAC4 (0.54) | HSD11B1HDAC4ALDH1A1 | |
| SCHEMBL31045569 | 0.68 | POLB (0.48) | HSD11B1HDAC4CHEK1KCNH2AVPR1A | |
| SCHEMBL28763224 | 0.68 | HSD11B1 (0.48) | HSD11B1HDAC4 | |
| SCHEMBL7604082 | 0.68 | HSD11B1 (0.35) | HSD11B1CHEK1KCNH2 | |
| SCHEMBL10897804 | 0.67 | HDAC4 (0.51) | HSD11B1HDAC4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7511141-B2 | Piperidine-piperazine ligands for neurotransmitter receptors | SEPRACOR, INC. (US) | 2009-03-31 | — | — | US | disclosed |
| US-20060063776-A1 | Piperidine-piperazine ligands for neurotransmitter receptors | PERSONS PAUL E | 2006-03-23 | — | — | US | disclosed |
| US-6936614-B2 | Piperidine-piperazine ligands for neurotransmitter receptors | SEPRACOR INC. (US) | 2005-08-30 | — | — | US | disclosed |
| US-20040254195-A1 | Piperidine-piperazine ligands for neurotransmitter receptors | PERSONS PAUL E (US) | 2004-12-16 | — | — | US | disclosed |
| US-6713479-B2 | LIGANDS FOR DOPAMINE, SEROTONIN OR NOREPINEPHRINE RECEPTORS OR TRANSPORTERS | SEPRACOR INC. | 2004-03-30 | — | — | US | disclosed |
| WO-2002069973-A1 | PIPERIDINE-PIPERAZINE LIGAND FOR NEUROTRANSMITTER RECEPTORS | SEPRACOR, INC. (US) | 2002-09-12 | — | — | WO | disclosed |
| US-20020123499-A1 | Piperidine-piperazine ligands for neurotransmitter receptors | SEPRACOR INC. | 2002-09-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060063776-A1 | Piperidine-piperazine ligands for neurotransmitter receptors | HTR5A, OPRL1, HTR2A | HSD11B1 1871/4885HDAC4 3356/4885CHEK1 3691/4885 |
| US-20020123499-A1 | Piperidine-piperazine ligands for neurotransmitter receptors | HTR5A, OPRL1, HTR2A | HSD11B1 1871/4885HDAC4 3356/4885CHEK1 3691/4885 |
| US-20040254195-A1 | Piperidine-piperazine ligands for neurotransmitter receptors | HTR5A, OPRL1, HTR2A | HSD11B1 1871/4885HDAC4 3356/4885CHEK1 3691/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.