SCHEMBL4476007

SCHEMBL4476007

Cc1cc2c(c(O)n1)C(=O)OCC2.Nc1ccc(F)cc1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 2/20 0.37
MAOA P21397 1/20 0.36
MAOB P27338 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.34
KDM4E B2RXH2 1/20 0.34
ALDH1A1 P00352 1/20 0.34
HPGD P15428 1/20 0.34
HSD17B10 Q99714 1/20 0.34
GRM5 P41594 2/20 0.32
NPC1 O15118 1/20 0.32
MAPT P10636 1/20 0.32
RAB9A P51151 1/20 0.32
PARP1 P09874 1/20 0.32
HSP90AA1 P07900 1/20 0.31
HSP90AB1 P08238 1/20 0.31
KMT2A Q03164 3/20 0.31
HTT P42858 1/20 0.31
MEN1 O00255 2/20 0.31
CTSL P07711 1/20 0.30
CTSB P07858 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4066514 0.86 GAA (0.43) GAAMAOAMAOBL3MBTL1KDM4E
SCHEMBL4072395 0.78 NPC1 (0.39) GAAMAOAMAOBL3MBTL1KDM4E
SCHEMBL4074481 0.77 TYK2 (0.38) L3MBTL1KDM4EALDH1A1HPGDHSD17B10
SCHEMBL4243371 0.77 GAA (0.37) GAAMAOAMAOBL3MBTL1KDM4E
SCHEMBL4070347 0.75 GAA (0.43) GAAMAOAMAOBL3MBTL1KDM4E
SCHEMBL4251098 0.72 ADORA2A (0.35) GAAL3MBTL1KDM4EALDH1A1HPGD
SCHEMBL4249021 0.72 TYK2 (0.34) L3MBTL1KDM4EALDH1A1HPGDHSD17B10
SCHEMBL4063497 0.72 KDM4E (0.44) GAAMAOAMAOBL3MBTL1KDM4E
SCHEMBL4072219 0.72 MAOA (0.38) GAAMAOAMAOBL3MBTL1KDM4E
SCHEMBL4065469 0.69 ALDH1A1 (0.43) GAAMAOAMAOBL3MBTL1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7601736-B2 Such as 3,4-dihydro-pyrano[3,4-c]pyridine-1-on; cytokine suppressive antiinflammatory drugs; analgesics SK CHEMICALS CO., LTD. (KR) 2009-10-13 US disclosed
US-20070254909-A1 Novel Pyridine Derivatives, a Process for Their Preparation and a Pharmaceutical Composition Containing the Same SK CHEMICALS CO., LTD. (KR) 2007-11-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070254909-A1 Novel Pyridine Derivatives, a Process for Their Preparation and a Pharmaceutical Composition Containing the Same IL5, IL1B, P2RY4 GAA 3796/4885MAOA 662/4885MAOB 760/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.