Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 3/20 | 0.46 |
| ▸ | TTK | P33981 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TNK2 | Q07912 | 3/20 | 0.32 |
| ▸ | USP7 | Q93009 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14813113 | 0.80 | DGAT1 (0.66) | DGAT1 | |
| SCHEMBL4933403 | 0.80 | DGAT1 (0.66) | DGAT1 | |
| SCHEMBL4472222 | 0.78 | ALDH1A1 (0.60) | DGAT1ALDH1A1POLB | |
| SCHEMBL4472609 | 0.70 | DGAT1 (0.52) | DGAT1ALDH1A1POLBUSP7 | |
| SCHEMBL4558482 | 0.70 | DGAT1 (0.52) | DGAT1ALDH1A1POLBUSP7 | |
| SCHEMBL4558171 | 0.70 | NPC1 (0.67) | DGAT1ALDH1A1POLB | |
| SCHEMBL4485345 | 0.70 | NPC1 (0.62) | DGAT1ALDH1A1POLB | |
| SCHEMBL4476143 | 0.64 | NPC1 (0.49) | DGAT1ALDH1A1 | |
| SCHEMBL27979910 | 0.64 | SLC18A3 (0.46) | ALDH1A1POLB | |
| SCHEMBL9291954 | 0.61 | HDAC4 (0.42) | DGAT1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2117526-A2 | INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE TYPE 1 ENZYME | Abbott Laboratories (US) | 2009-11-18 | — | — | EP | claimed |
| WO-2008067257-A2 | INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE TYPE 1 ENZYME | ABBOTT LABORATORIES (US) | 2008-06-05 | — | — | WO | claimed |
| EP-2117526-A2 | INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE TYPE 1 ENZYME | Abbott Laboratories (US) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008067257-A2 | INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE TYPE 1 ENZYME | ABBOTT LABORATORIES (US) | 2008-06-05 | — | — | WO | disclosed |