Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | DGAT1 | O75907 | 5/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 5/20 | 0.35 |
| ▸ | RAB9A | P51151 | 5/20 | 0.35 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | EGLN2 | Q96KS0 | 4/20 | 0.34 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4476872 | 0.78 | DGAT1 (0.46) | ALDH1A1POLBDGAT1 | |
| SCHEMBL4558171 | 0.77 | NPC1 (0.67) | ALDH1A1POLBDGAT1NPC1RAB9A | |
| SCHEMBL4474205 | 0.77 | MBOAT4 (0.38) | ALDH1A1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL5593173 | 0.75 | ALDH1A1 (0.72) | ALDH1A1POLBDGAT1GAANPC1 | |
| SCHEMBL4472609 | 0.75 | DGAT1 (0.52) | ALDH1A1POLBDGAT1NPC1RAB9A | |
| SCHEMBL4485345 | 0.75 | NPC1 (0.62) | ALDH1A1POLBDGAT1NPC1RAB9A | |
| SCHEMBL4558482 | 0.75 | DGAT1 (0.52) | ALDH1A1POLBDGAT1NPC1RAB9A | |
| SCHEMBL4476143 | 0.69 | NPC1 (0.49) | ALDH1A1DGAT1NPC1RAB9AMEN1 | |
| SCHEMBL14163226 | 0.65 | DGAT1 (0.75) | ALDH1A1POLBDGAT1NPC1RAB9A | |
| SCHEMBL27979910 | 0.64 | SLC18A3 (0.46) | ALDH1A1POLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2117526-A2 | INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE TYPE 1 ENZYME | Abbott Laboratories (US) | 2009-11-18 | — | — | EP | claimed |
| WO-2008067257-A2 | INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE TYPE 1 ENZYME | ABBOTT LABORATORIES (US) | 2008-06-05 | — | — | WO | claimed |
| EP-2117526-A2 | INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE TYPE 1 ENZYME | Abbott Laboratories (US) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008067257-A2 | INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE TYPE 1 ENZYME | ABBOTT LABORATORIES (US) | 2008-06-05 | — | — | WO | disclosed |