SCHEMBL4477586

SCHEMBL4477586

O=C(OOC(=O)c1cccc(Cl)c1Cl)c1ccccc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
F2 P00734 1/20 0.59
LMNA P02545 1/20 0.59
TSHR P16473 2/20 0.56
L3MBTL1 Q9Y468 3/20 0.46
PKM P14618 2/20 0.46
NPC1 O15118 1/20 0.46
GAA P10253 1/20 0.46
HPGD P15428 1/20 0.46
NFKB1 P19838 1/20 0.46
RAB9A P51151 1/20 0.46
NFKB2 Q00653 1/20 0.46
RELA Q04206 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
ERCC5 P28715 1/20 0.46
FEN1 P39748 1/20 0.46
ALDH1A1 P00352 2/20 0.46
P2RX7 Q99572 2/20 0.43
ALOX12 P18054 1/20 0.43
HSD17B10 Q99714 1/20 0.43
TDP1 Q9NUW8 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29566931 0.89 TSHR (0.63) LMNATSHRL3MBTL1PKMERCC5
SCHEMBL36590 0.89 TSHR (0.63) LMNATSHRL3MBTL1PKMERCC5
SCHEMBL11422207 0.87 LMNA (0.65) F2LMNATSHRL3MBTL1PKM
SCHEMBL5955453 0.86 TSHR (0.56) F2LMNATSHRL3MBTL1PKM
Benzoyl Peroxide SCHEMBL15090497 0.83 LMNA (0.77) F2LMNATSHRL3MBTL1PKM
Isopropylbenzene SCHEMBL6796969 0.82 TSHR (0.51) LMNATSHRL3MBTL1NPC1HPGD
Benzoyl Peroxide SCHEMBL27789821 0.81 F2 (0.61) F2LMNATSHRL3MBTL1PKM
SCHEMBL28767306 0.79 MAPK1 (0.49) LMNATSHRL3MBTL1PKMHPGD
SCHEMBL30403796 0.78 TSHR (0.64) LMNATSHRL3MBTL1PKMGAA
SCHEMBL334531 0.78 TSHR (0.64) LMNATSHRL3MBTL1PKMGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0966494-B1 TRAFFIC PAINT COMPOSITIONS AND METHOD FOR REDUCING THE DELAY FOR RESUMPTION OF TRAFFIC ON A NEWLY MARKED ROAD APPLIC ROUTIERES S A S SOC D (FR) 2002-07-03 EP claimed
EP-1071482-B1 INTRAOCULAR LENS COATING COMPOSITIONS ALCON LAB INC (US) 2001-10-04 EP claimed
EP-2041218-B1 COMPOSITION BASED ON ORGANOSILICON COMPOUNDS WACKER CHEMIE AG (DE) 2009-09-23 EP disclosed
EP-2041218-A1 COMPOSITION BASED ON ORGANOSILICON COMPOUNDS Wacker Chemie AG (DE) 2009-04-01 EP disclosed
WO-2008009555-A1 COMPOSITION BASED ON ORGANOSILICON COMPOUNDS WACKER CHEMIE AG (DE) 2008-01-24 WO disclosed
EP-0563749-B1 Automatically mixable product for making crowns and bridges MUEHLBAUER ERNST KG (DE) 1996-01-03 EP disclosed
US-5376691-A A radiopaque curable pressed mixture of two pastes, the first paste containing a difunctional acrylates, a radiopaque filler , second paste containing a nonpolymerizable softener and a polymerization catalysts; bubble free, break-resistance Ernst Muhlbaner KG (DE) 1994-12-27 US disclosed
EP-0563749-A1 Automatically mixable product for making crowns and bridges ERNST MÜHLBAUER KG (DE) 1993-10-06 EP disclosed
EP-0324860-A1 RUBBER COMPOSITION NIPPON ZEON CO., LTD. (JP) 1989-07-26 EP disclosed
EP-0239961-A2 A silicone rubber composition Shin-Etsu Chemical Co., Ltd. (JP) 1987-10-07 EP disclosed