Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 7/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.56 |
| ▸ | MAPT | P10636 | 7/20 | 0.56 |
| ▸ | HTT | P42858 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | LMNA | P02545 | 7/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MITF | O75030 | 3/20 | 0.52 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.52 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.52 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | MMP13 | P45452 | 1/20 | 0.50 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17104295 | 0.85 | SMN1; SMN2 (0.69) | MEN1KMT2ASMN1; SMN2MAPTHTT | |
| SCHEMBL8349308 | 0.82 | MEN1 (0.58) | MEN1KMT2ASMN1; SMN2MAPTHTT | |
| SCHEMBL4479971 | 0.81 | MEN1 (0.55) | MEN1KMT2ASMN1; SMN2MAPTHTT | |
| SCHEMBL17104322 | 0.76 | MEN1 (0.48) | MEN1KMT2ASMN1; SMN2MAPTHTT | |
| SCHEMBL4281848 | 0.75 | LMNA (0.62) | MEN1KMT2ASMN1; SMN2MAPTHTT | |
| SCHEMBL17104327 | 0.75 | MEN1 (0.47) | MEN1KMT2ASMN1; SMN2MAPTHTT | |
| SCHEMBL6396333 | 0.74 | LMNA (0.79) | MEN1KMT2ASMN1; SMN2MAPTHTT | |
| SCHEMBL22686988 | 0.74 | RAB9A (0.55) | MEN1KMT2ASMN1; SMN2MAPTHTT | |
| SCHEMBL15055075 | 0.73 | HSPB1 (0.55) | MEN1KMT2ASMN1; SMN2MAPTHTT | |
| SCHEMBL4481435 | 0.73 | HSPB1 (0.58) | MEN1KMT2ASMN1; SMN2MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1503986-B1 | COMPOSITIONS AND METHODS FOR TREATING HEART FAILURE | CYTOKINETICS INC (US) | 2015-09-30 | — | — | EP | claimed |
| US-7605164-B2 | Compositions and methods for treating heart failure | CYTOKINETICS, INC. (US) | 2009-10-20 | — | — | US | claimed |