Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.46 |
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.38 |
| ▸ | SCN10A | Q9Y5Y9 | 7/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.38 |
| ▸ | SCN1A | P35498 | 1/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.38 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.38 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4483092 | 0.82 | RAB9A (0.39) | RAB9ANPC1SMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL9061793 | 0.82 | NPC1 (0.59) | RAB9ANPC1SMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL9060178 | 0.81 | NPC1 (0.57) | RAB9ANPC1SMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL9062389 | 0.80 | RARB (0.50) | RAB9ANPC1SMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL9061248 | 0.80 | NPC1 (0.56) | RAB9ANPC1SMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL9060818 | 0.78 | NPC1 (0.55) | RAB9ANPC1SMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL9062023 | 0.78 | RAB9A (0.55) | RAB9ANPC1SMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL9061575 | 0.78 | RARB (0.49) | RAB9ANPC1SMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL9061383 | 0.78 | RAB9A (0.55) | RAB9ANPC1SMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL5351824 | 0.78 | RARB (0.56) | RAB9ANPC1SMN1; SMN2KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7579353-B2 | Pyridinone derivatives against malaria | GLAXO GROUP LIMITED (GB) | 2009-08-25 | — | — | US | disclosed |
| US-20080287461-A1 | Pyridinone Derivatives Against Malaria | GLAXO GROUP LIMITED (GB) | 2008-11-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080287461-A1 | Pyridinone Derivatives Against Malaria | G6PD, PNPO, PLPBP | RAB9A 2000/4885NPC1 2243/4885SMN1; SMN2 1885/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.