Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 4/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.41 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.41 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23537244 | 0.83 | P2RX4 (0.39) | NOTUMPOLBALDH1A1HPGDKDM4E | |
| SCHEMBL887130 | 0.69 | CREBBP (0.55) | NOTUMPOLBCREBBPBRPF1BRD9 | |
| SCHEMBL8149494 | 0.69 | CYP2A6 (0.41) | BRD9ALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL19234093 | 0.67 | ALDH1A1 (0.39) | ALDH1A1HPGDKDM4EHSD17B10KMT2A | |
| SCHEMBL18986766 | 0.67 | LDHA (0.40) | POLBALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL15880060 | 0.66 | NOTUM (0.47) | NOTUMPOLBELANEALDH1A1HPGD | |
| SCHEMBL30561525 | 0.65 | HSD17B10 (0.38) | HTTALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL3640203 | 0.65 | KMT2A (0.38) | POLBALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL1333179 | 0.65 | HTT (0.54) | NOTUMPOLBCREBBPBRPF1BRD9 | |
| SCHEMBL887129 | 0.65 | HTT (0.54) | NOTUMPOLBCREBBPBRPF1BRD9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616808-B1 | PROLYL ENDOPEPTIDASE PROBES | STANFORD RES INST INT (US) | 2015-02-25 | — | — | EP | disclosed |
| US-20120065103-A1 | Prolyl Endopeptidase Probes | SRI INTERNATIONAL | 2012-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120065103-A1 | Prolyl Endopeptidase Probes | PREP, XPNPEP1, ANPEP | NOTUM 1014/4885POLB 1942/4885CREBBP 2472/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.