Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.30 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.30 |
| ▸ | CDC42 | P60953 | 3/20 | 0.30 |
| ▸ | RAC1 | P63000 | 3/20 | 0.30 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.30 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.30 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14841967 | 0.79 | NR1H2 (0.39) | NR1H2CSNK1E | |
| SCHEMBL14841682 | 0.67 | CREBBP (0.35) | CSNK1E | |
| SCHEMBL2753361 | 0.67 | GRM5 (0.41) | NR1H2RAB9A | |
| SCHEMBL2752518 | 0.64 | MKNK1 (0.40) | — | |
| SCHEMBL2753740 | 0.63 | THRB (0.38) | RAB9A | |
| SCHEMBL5380065 | 0.62 | SIGMAR1 (0.64) | SIGMAR1 | |
| SCHEMBL28734987 | 0.61 | PDK2 (0.40) | — | |
| SCHEMBL27233042 | 0.61 | PDK2 (0.40) | — | |
| SCHEMBL15152267 | 0.61 | SPR (0.40) | NPC1RAB9A | |
| SCHEMBL27920635 | 0.61 | NOTUM (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |