Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | TEAD1 | P28347 | 3/20 | 0.47 |
| ▸ | RBP4 | P02753 | 2/20 | 0.47 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | TACR1 | P25103 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4476067 | 1.00 | SIGMAR1 (0.53) | SIGMAR1KDM4ETEAD1RBP4MRGPRX1 | |
| SCHEMBL19970345 | 1.00 | SIGMAR1 (0.53) | SIGMAR1KDM4ETEAD1RBP4MRGPRX1 | |
| SCHEMBL19970343 | 0.94 | SIGMAR1 (0.56) | SIGMAR1KDM4ETEAD1RBP4MRGPRX1 | |
| SCHEMBL5119863 | 0.93 | KDM4E (0.53) | SIGMAR1KDM4ERBP4MRGPRX1ALDH1A1 | |
| SCHEMBL4486493 | 0.85 | P2RX7 (0.48) | TEAD1BCHEACHEBACE1P2RX7 | |
| SCHEMBL4484252 | 0.85 | TEAD1 (0.45) | SIGMAR1TEAD1BCHEACHEBACE1 | |
| SCHEMBL16269040 | 0.84 | SCN9A (0.51) | SIGMAR1KDM4ETACR1P2RX7CYP2C9 | |
| SCHEMBL5758822 | 0.84 | SCN9A (0.51) | SIGMAR1KDM4ETACR1P2RX7CYP2C9 | |
| SCHEMBL19970346 | 0.82 | CYP2C9 (0.47) | SIGMAR1KDM4ERBP4ALDH1A1MEN1 | |
| SCHEMBL19970340 | 0.82 | CYP2C9 (0.47) | SIGMAR1KDM4ERBP4ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7619096-B2 | 3-Aminopyrrolidines as inhibitors of monoamine uptake | ELI LILLY AND COMPANY (US) | 2009-11-17 | — | — | US | disclosed |
| EP-1638934-B1 | 3-AMINOPYRROLIDINES AS INHIBITORS OF MONOAMINE UPTAKE | LILLY CO ELI (US) | 2008-01-09 | — | — | EP | disclosed |
| US-20060270713-A1 | 3-Aminopyrrolidines as inhibitors of monoamine uptake | ELI LILLY AND COMPANY | 2006-11-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060270713-A1 | 3-Aminopyrrolidines as inhibitors of monoamine uptake | SLC6A2, SLC6A3, SLC18A2 | SIGMAR1 166/4885KDM4E 1943/4885TEAD1 1983/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.