Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | NOS1 | P29475 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 3/20 | 0.38 |
| ▸ | HTR2B | P41595 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5238590 | 0.78 | NOS1 (0.44) | KMT2AGAAMEN1NOS1NPC1 | |
| SCHEMBL14463608 | 0.78 | NOS1 (0.44) | KMT2AGAAMEN1NOS1NPC1 | |
| SCHEMBL21745146 | 0.76 | GAA (0.56) | KMT2AGAAMEN1NOS1HTR2C | |
| SCHEMBL21745144 | 0.76 | GAA (0.56) | KMT2AGAAMEN1NOS1HTR2C | |
| SCHEMBL21762794 | 0.76 | GAA (0.56) | KMT2AGAAMEN1NOS1HTR2C | |
| SCHEMBL6422828 | 0.76 | HTR2C (0.54) | HTR2CHTR2BHTR2A | |
| SCHEMBL3087214 | 0.75 | MEN1 (0.37) | KMT2AGAAMEN1NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL6422741 | 0.74 | HTR2C (0.52) | HTR2CHTR2BHTR2A | |
| SCHEMBL30600476 | 0.74 | BCHE (0.41) | KMT2AGAAMEN1KDM4EALDH1A1 | |
| SCHEMBL180964 | 0.74 | BCHE (0.41) | KMT2AGAAMEN1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7579343-B2 | Pyrrolo-thiazines and processes for the preparation and use thereof | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2009-08-25 | — | — | US | disclosed |
| EP-1934232-A2 | PYRROLO-THIAZINES AND PROCESSES FOR THE PREPARATION AND USE THEREOF | MICHIGAN STATE UNIVERSITY (US) | 2008-06-25 | — | — | EP | disclosed |
| WO-2007030487-A2 | PYRROLO-THIAZINES AND PROCESSES FOR THE PREPARATION AND USE THEREOF | MICHIGAN STATE UNIVERSITY (US) | 2007-03-15 | — | — | WO | disclosed |
| US-20070055062-A1 | Pyrrolo-thiazines and processes for the preparation and use thereof | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2007-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070055062-A1 | Pyrrolo-thiazines and processes for the preparation and use thereof | TALDO1, THPO, PPOX | KMT2A 3214/4885GAA 59/4885MEN1 1529/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.