Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.36 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4482399 | 1.00 | ALDH1A1 (0.42) | ALDH1A1GAAPOLBPTGS2TDP1 | |
| SCHEMBL6205786 | 0.89 | ALDH1A1 (0.50) | ALDH1A1GAAPOLBPTGS2TDP1 | |
| SCHEMBL6205783 | 0.89 | ALDH1A1 (0.50) | ALDH1A1GAAPOLBPTGS2TDP1 | |
| SCHEMBL4469564 | 0.88 | PTGS2 (0.51) | ALDH1A1POLBPTGS2TDP1HTT | |
| SCHEMBL4469574 | 0.88 | PTGS2 (0.51) | ALDH1A1POLBPTGS2TDP1HTT | |
| SCHEMBL4485374 | 0.87 | POLB (0.52) | ALDH1A1GAAPOLBPTGS2TDP1 | |
| SCHEMBL4467387 | 0.87 | POLB (0.52) | ALDH1A1GAAPOLBPTGS2TDP1 | |
| SCHEMBL4464159 | 0.86 | MAPT (0.45) | ALDH1A1GAAPOLBPTGS2TDP1 | |
| SCHEMBL4464157 | 0.86 | MAPT (0.45) | ALDH1A1GAAPOLBPTGS2TDP1 | |
| SCHEMBL4475955 | 0.84 | PTGS1 (0.53) | ALDH1A1GAAPOLBPTGS2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582630-B2 | Pyradazine compounds as GSK-3 inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 2009-09-01 | — | — | US | disclosed |
| US-20060069097-A1 | Pyradazine compounds as gsk-3 inhibitors | SMITHKLINE BEECHAM CORPORATION | 2006-03-30 | — | — | US | disclosed |
| EP-1551842-A1 | PYRADAZINE COMPOUNDS AS GSK-3 INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-07-13 | — | — | EP | disclosed |
| WO-2004035588-A1 | PYRADAZINE COMPOUNDS AS GSK-3 INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-04-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060069097-A1 | Pyradazine compounds as gsk-3 inhibitors | GSK3B, GSK3A, GSKIP | ALDH1A1 4212/4885GAA 2919/4885POLB 2886/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.