Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 17/20 | 0.80 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.55 |
| ▸ | PRKCG | P05129 | 2/20 | 0.55 |
| ▸ | PRKCB | P05771 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.55 |
| ▸ | PRKCA | P17252 | 2/20 | 0.55 |
| ▸ | PRKACA | P17612 | 2/20 | 0.55 |
| ▸ | PRKACG | P22612 | 2/20 | 0.55 |
| ▸ | PRKACB | P22694 | 2/20 | 0.55 |
| ▸ | PRKCH | P24723 | 2/20 | 0.55 |
| ▸ | PRKCI | P41743 | 2/20 | 0.55 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.55 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.55 |
| ▸ | PRKCZ | Q05513 | 2/20 | 0.55 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.55 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4482643 | 0.91 | HTR6 (0.66) | HTR6PRKD3PRKCGPRKCBCYP3A4 | |
| SCHEMBL1136444 | 0.89 | HTR6 (1.00) | HTR6 | |
| SCHEMBL4473400 | 0.84 | HTR6 (1.00) | HTR6 | |
| SCHEMBL4472828 | 0.83 | HTR6 (0.82) | HTR6CYP3A4CYP1A2MEN1CYP2D6 | |
| SCHEMBL1136481 | 0.81 | HTR6 (0.75) | HTR6 | |
| SCHEMBL4483013 | 0.81 | HTR6 (0.84) | HTR6 | |
| SCHEMBL4473710 | 0.79 | HTR6 (0.85) | HTR6 | |
| SCHEMBL1136476 | 0.79 | HTR6 (1.00) | HTR6 | |
| SCHEMBL4482899 | 0.78 | HTR6 (1.00) | HTR6MEN1KMT2A | |
| SCHEMBL4490191 | 0.78 | HTR6 (0.76) | HTR6KDM4EKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8377931-B2 | Benzoxazine derivatives and uses thereof | ROCHE PALO ALTO LLC (US) | 2013-02-19 | — | — | US | claimed |
| US-20090325950-A1 | Benzoxazine derivatives and uses thereof | ROCHE PALO ALTO LLC | 2009-12-31 | — | — | US | claimed |
| US-20130123251-A1 | BENZOXAZINE DERIVATIVES AND USES THEREOF | ROCHE PALO ALTO LLC (US) | 2013-05-16 | — | — | US | disclosed |
| US-20130123251-A1 | BENZOXAZINE DERIVATIVES AND USES THEREOF | ROCHE PALO ALTO LLC (US) | 2013-05-16 | — | — | US | disclosed |
| US-20130123251-A1 | BENZOXAZINE DERIVATIVES AND USES THEREOF | ROCHE PALO ALTO LLC (US) | 2013-05-16 | — | — | US | disclosed |
| US-8377931-B2 | Benzoxazine derivatives and uses thereof | ROCHE PALO ALTO LLC (US) | 2013-02-19 | — | — | US | disclosed |
| US-8377931-B2 | Benzoxazine derivatives and uses thereof | ROCHE PALO ALTO LLC (US) | 2013-02-19 | — | — | US | disclosed |
| US-8377931-B2 | Benzoxazine derivatives and uses thereof | ROCHE PALO ALTO LLC (US) | 2013-02-19 | — | — | US | disclosed |
| US-20090325950-A1 | Benzoxazine derivatives and uses thereof | ROCHE PALO ALTO LLC | 2009-12-31 | — | — | US | disclosed |
| US-20090325950-A1 | Benzoxazine derivatives and uses thereof | ROCHE PALO ALTO LLC | 2009-12-31 | — | — | US | disclosed |
| US-20090325950-A1 | Benzoxazine derivatives and uses thereof | ROCHE PALO ALTO LLC | 2009-12-31 | — | — | US | disclosed |
| EP-1506179-B1 | BENZOXAZINE DERIVATIVES AS 5-HT6 MODULATORS AND USES THEREOF | HOFFMANN LA ROCHE (CH) | 2006-01-25 | — | — | EP | disclosed |
| US-20050130962-A1 | Benzoxazine derivatives and uses thereof | BERGER JACOB (US) | 2005-06-16 | — | — | US | disclosed |
| US-6867204-B2 | Benzoxazine derivatives and uses thereof | ROCHE PALO ALTO LLC (US) | 2005-03-15 | — | — | US | disclosed |
| EP-1506179-A1 | BENZOXAZINE DERIVATIVES AS 5-HT6 MODULATORS AND USES THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2005-02-16 | — | — | EP | disclosed |
| US-20030232825-A1 | Benzoxazine derivatives and uses thereof | ROCHE PALO ALTO LLC | 2003-12-18 | — | — | US | disclosed |
| WO-2003095434-A1 | BENZOXAZINE DERIVATIVES AS 5-HT6 MODULATORS AND USES THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2003-11-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090325950-A1 | Benzoxazine derivatives and uses thereof | F12, CYP4X1, CYP3A5 | HTR6 2321/4885PRKD3 2266/4885PRKCG 3878/4885 |
| US-20050130962-A1 | Benzoxazine derivatives and uses thereof | F12, HAX1, CYP4X1 | HTR6 2220/4885PRKD3 2196/4885PRKCG 4038/4885 |
| US-20030232825-A1 | Benzoxazine derivatives and uses thereof | CYP3A5, CYP4X1, XDH | HTR6 1363/4885PRKD3 2225/4885PRKCG 3819/4885 |
| US-20130123251-A1 | BENZOXAZINE DERIVATIVES AND USES THEREOF | F12, CYP4X1, CYP3A5 | HTR6 2321/4885PRKD3 2266/4885PRKCG 3878/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.