Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.68 |
| ▸ | HPGD | P15428 | 2/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.68 |
| ▸ | MAPT | P10636 | 1/20 | 0.68 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | HTR3E | A5X5Y0 | 3/20 | 0.60 |
| ▸ | HTR3B | O95264 | 3/20 | 0.60 |
| ▸ | HTR3A | P46098 | 3/20 | 0.60 |
| ▸ | HTR3D | Q70Z44 | 3/20 | 0.60 |
| ▸ | HTR3C | Q8WXA8 | 3/20 | 0.60 |
| ▸ | HTR1A | P08908 | 2/20 | 0.60 |
| ▸ | HTR2C | P28335 | 2/20 | 0.60 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | NCF1 | P14598 | 1/20 | 0.58 |
| ▸ | ACHE | P22303 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6231748 | 0.90 | HRH4 (0.58) | LMNAALDH1A1HPGDKDM4EMAPT | |
| Bromide SCHEMBL6236006 | 0.89 | HRH4 (0.57) | LMNAALDH1A1HPGDKDM4EMAPT | |
| SCHEMBL4480012 | 0.81 | L3MBTL1 (0.63) | LMNAALDH1A1HPGDKDM4EMAPT | |
| SCHEMBL7244839 | 0.78 | HRH4 (1.00) | HRH4CYP1A2HTR3EHTR3BHTR3A | |
| SCHEMBL30223018 | 0.78 | HRH4 (1.00) | HRH4CYP1A2HTR3EHTR3BHTR3A | |
| SCHEMBL7234909 | 0.77 | CYP1A2 (1.00) | ALDH1A1HPGDKDM4EMAPTHRH4 | |
| SCHEMBL30155519 | 0.76 | ALDH1A1 (0.63) | LMNAALDH1A1HPGDKDM4EMAPT | |
| SCHEMBL7243632 | 0.76 | CYP1A2 (0.96) | ALDH1A1HPGDKDM4EMAPTHRH4 | |
| SCHEMBL31737287 | 0.75 | RECQL (0.57) | LMNAALDH1A1HPGDKDM4EMAPT | |
| SCHEMBL7234029 | 0.75 | HRH4 (0.61) | LMNAALDH1A1KDM4EHRH4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7494992-B2 | Antiparasitic terpene alkaloids | PFIZER INC. (US) | 2009-02-24 | — | — | US | disclosed |
| US-20070185101-A1 | Antiparasitic terpene alkaloids | PFIZER PRODUCTS INC | 2007-08-09 | — | — | US | disclosed |
| CN-1809576-A | Antiparasitic terpene alkaloids | PFIZER (US) | 2006-07-26 | — | — | CN | disclosed |
| EP-1597264-A2 | ANTIPARASITIC TERPENE ALKALOIDS | Pfizer Limited (GB) | 2005-11-23 | — | — | EP | disclosed |
| WO-2004072086-A2 | ANTIPARASITIC TERPENE ALKALOIDS | PFIZER LIMITED (GB) | 2004-08-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185101-A1 | Antiparasitic terpene alkaloids | CYP51A1, DHPS, CYP8B1 | LMNA 3892/4885ALDH1A1 441/4885HPGD 1310/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.