Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 5/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | STAT1 | P42224 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | CTSC | P53634 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.44 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.43 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.43 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.43 |
| ▸ | QDPR | P09417 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15437161 | 0.88 | EPHX2 (0.46) | EPHX2RAB9ANPC1MAPTSTAT1 | |
| SCHEMBL15692311 | 0.86 | EPHX2 (0.57) | EPHX2RAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL11439049 | 0.86 | QDPR (0.59) | RAB9ANPC1MAPTSTAT1SMN1; SMN2 | |
| SCHEMBL19097366 | 0.86 | EPHX2 (0.57) | EPHX2NAMPTP2RY14GRM5MCHR1 | |
| SCHEMBL27957954 | 0.84 | EPHX2 (0.58) | EPHX2NPC1MAPTSMN1; SMN2CTSC | |
| SCHEMBL4034093 | 0.84 | ALDH1A1 (0.57) | EPHX2RAB9ANPC1MAPTSTAT1 | |
| SCHEMBL10265353 | 0.84 | NPC1 (0.48) | EPHX2RAB9ANPC1MAPTSTAT1 | |
| SCHEMBL24478306 | 0.83 | RAB9A (0.54) | RAB9ANPC1MAPTSTAT1SMN1; SMN2 | |
| SCHEMBL15686707 | 0.82 | EPHX2 (0.60) | EPHX2SMN1; SMN2CTSCNAMPTALDH1A1 | |
| SCHEMBL24478307 | 0.82 | MAPT (0.50) | EPHX2RAB9ANPC1MAPTSTAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120108566-A1 | NICOTINAMIDES AS JAK KINASE MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120108566-A1 | NICOTINAMIDES AS JAK KINASE MODULATORS | JAK2, JAK1, NADK | EPHX2 2126/4885RAB9A 2487/4885NPC1 949/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.