SCHEMBL44850

SCHEMBL44850

O=C(O)c1cc(/C=N\O)nn1-c1ncccc1Cl

nearest known ligand 0.38

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
MALT1 Q9UDY8 3/20 0.35
TRPA1 O75762 2/20 0.33
AVPR1A P37288 2/20 0.33
LMNA P02545 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
ALOX15 P16050 2/20 0.33
KDM4E B2RXH2 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
RARG P13631 2/20 0.32
RORC P51449 2/20 0.32
HTT P42858 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL44851 1.00 MALT1 (0.35) MALT1TRPA1AVPR1ALMNASMN1; SMN2
SCHEMBL951154 0.86 MALT1 (0.34) MALT1TRPA1RARGRORC
SCHEMBL340411 0.86 ALOX15 (0.45) MALT1TRPA1AVPR1AALOX15KDM4E
SCHEMBL340412 0.86 ALOX15 (0.45) MALT1TRPA1AVPR1AALOX15KDM4E
SCHEMBL951152 0.86 MALT1 (0.34) MALT1TRPA1RARGRORC
SCHEMBL17135611 0.86 LMNA (0.39) MALT1TRPA1LMNASMN1; SMN2MEN1
SCHEMBL12528590 0.85 MALT1 (0.36) MALT1TRPA1LMNASMN1; SMN2MEN1
SCHEMBL384656 0.80 KMT2A (0.43) MALT1LMNASMN1; SMN2MEN1KMT2A
SCHEMBL958268 0.80 MALT1 (0.40) MALT1TRPA1LMNASMN1; SMN2RARG
SCHEMBL29558300 0.80 MALT1 (0.40) MALT1TRPA1LMNASMN1; SMN2RARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2582688-B1 ANTHRANILIC ACID DIAMIDE DERIVATIVES BAYER IP GMBH (DE) 2015-10-07 EP disclosed
EP-2582688-A1 ANTHRANILIC ACID DIAMIDE DERIVATIVES Bayer Intellectual Property GmbH (DE) 2013-04-24 EP disclosed
WO-2011157654-A1 ANTHRANILIC ACID DIAMIDE DERIVATIVES BAYER CROPSCIENCE AG (DE) 2011-12-22 WO disclosed