Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 18/20 | 0.45 |
| ▸ | HRH1 | P35367 | 2/20 | 0.44 |
| ▸ | CCR3 | P51677 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4478245 | 0.74 | HRH3 (0.48) | HRH3HRH1CCR3KCNH2CYP2D6 | |
| SCHEMBL4474695 | 0.73 | HRH3 (0.48) | HRH3 | |
| SCHEMBL3777354 | 0.73 | HRH3 (0.58) | HRH3HRH1MEN1KMT2AKCNH2 | |
| SCHEMBL4479047 | 0.72 | HRH3 (0.46) | HRH3KCNH2CYP2D6 | |
| SCHEMBL3776595 | 0.71 | HRH3 (0.62) | HRH3KCNH2CYP2D6 | |
| SCHEMBL4481591 | 0.67 | HRH1 (0.42) | HRH1CCR3MEN1KMT2A | |
| SCHEMBL4672614 | 0.67 | HRH3 (0.64) | HRH3HRH1MEN1KMT2AKCNH2 | |
| SCHEMBL4239422 | 0.66 | HRH3 (0.63) | HRH3HRH1MEN1KMT2AKCNH2 | |
| Hydrochloric Acid SCHEMBL4239663 | 0.65 | HRH3 (0.65) | HRH3HRH1MEN1KMT2AKCNH2 | |
| SCHEMBL10247726 | 0.65 | HRH3 (0.62) | HRH3HRH1CCR3CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009039431-A2 | SUBSTITUTED ARYL-FUSED SPIROCYCLIC AMINES | NEUROGEN CORPORATION (US) | 2009-03-26 | — | — | WO | disclosed |