Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | PPARD | Q03181 | 1/20 | 0.33 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.33 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.31 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.31 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.31 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
| ▸ | EP300 | Q09472 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL448243 | 0.95 | MAPT (0.40) | MAPTLCKPPARDZDHHC20ZDHHC2 | |
| SCHEMBL445918 | 0.94 | MAPT (0.42) | MAPTLCKPPARDZDHHC20ZDHHC2 | |
| SCHEMBL451026 | 0.92 | CHRM1 (0.32) | — | |
| SCHEMBL3166697 | 0.84 | — | — | |
| SCHEMBL449847 | 0.84 | — | — | |
| SCHEMBL6472685 | 0.74 | CA2 (0.42) | CA2MAPK1MAPTLCKPPARD | |
| SCHEMBL8060421 | 0.73 | ACHE (0.49) | CA2MAPK1MAPTLCKPPARD | |
| SCHEMBL4946239 | 0.73 | CA2 (0.41) | CA2MAPK1MAPTLCKPPARD | |
| SCHEMBL22500748 | 0.73 | CA2 (0.41) | CA2MAPK1MAPTLCKPPARD | |
| SCHEMBL28279029 | 0.73 | CA2 (0.41) | CA2MAPK1MAPTLCKPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2307190-B1 | SILICONE-CONTAINING POLYMERIC MATERALS WITH HYDROLYZABLE GROUPS | NOVARTIS AG (CH) | 2015-03-18 | — | — | EP | disclosed |
| US-8883928-B2 | Silicone-containing polymeric materials with hydrolyzable groups | NOVARTIS AG (CH) | 2014-11-11 | — | — | US | disclosed |
| US-20120065331-A1 | SILICONE-CONTAINING POLYMERIC MATERIALS WITH HYDROLYZABLE GROUPS | ALCON INC. (CH) | 2012-03-15 | — | — | US | disclosed |
| US-8079703-B2 | Silicone-containing polymeric materials with hydrolyzable groups | NOVARTIS AG (CH) | 2011-12-20 | — | — | US | disclosed |
| EP-2307190-A1 | SILICONE-CONTAINING POLYMERIC MATERALS WITH HYDROLYZABLE GROUPS | Novartis AG (CH) | 2011-04-13 | — | — | EP | disclosed |
| WO-2010011493-A1 | SILICONE-CONTAINING POLYMERIC MATERALS WITH HYDROLYZABLE GROUPS | NOVARTIS AG (CH) | 2010-01-28 | — | — | WO | disclosed |
| US-20100014047-A1 | Silicone-Containing Polymeric Materials with Hydrolyzable Groups | ALCON INC. (CH) | 2010-01-21 | — | — | US | disclosed |