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Sugi Predict / Compounds / SCHEMBL4486700

SCHEMBL4486700

SCHEMBL4486700

CCN(C(=O)CN(C)C)c1ccc(N/C(=C2\C(=O)Nc3cc(Cl)ccc32)c2ccccc2)cc1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HPGD P15428 1/20 0.35
▸ TSHR P16473 1/20 0.35
▸ MEN1 O00255 2/20 0.34
▸ KMT2A Q03164 2/20 0.34
▸ RXFP1 Q9HBX9 1/20 0.34
▸ MAPT P10636 3/20 0.34
▸ GAA P10253 2/20 0.34
▸ HTT P42858 2/20 0.34
▸ NPSR1 Q6W5P4 2/20 0.34
▸ ALDH1A1 P00352 1/20 0.34
▸ LRRK2 Q5S007 1/20 0.34
▸ CYP19A1 P11511 1/20 0.33
▸ SMN1; SMN2 Q16637 1/20 0.33
▸ CSF1R P07333 1/20 0.33
▸ KDR P35968 2/20 0.33
▸ MCL1 Q07820 1/20 0.33
▸ MAPK8 P45983 1/20 0.33
▸ KIT P10721 1/20 0.33
▸ FLT4 P35916 1/20 0.33
▸ FLT3 P36888 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4486706 1.00 HPGD (0.35) HPGDTSHRMEN1KMT2ARXFP1
SCHEMBL4484095 0.93 SLC6A9 (0.34) TSHRMEN1KMT2ARXFP1MAPT
SCHEMBL4484104 0.93 SLC6A9 (0.34) TSHRMEN1KMT2ARXFP1MAPT
SCHEMBL4485894 0.92 ALDH1A1 (0.37) HPGDRXFP1MAPTGAAHTT
SCHEMBL4485898 0.92 ALDH1A1 (0.37) HPGDRXFP1MAPTGAAHTT
SCHEMBL4500471 0.90 ALDH1A1 (0.37) KMT2ARXFP1MAPTNPSR1ALDH1A1
SCHEMBL4500472 0.90 ALDH1A1 (0.37) KMT2ARXFP1MAPTNPSR1ALDH1A1
SCHEMBL2572730 0.88 SENP1 (0.38) HPGDMEN1KMT2ARXFP1MAPT
SCHEMBL479677 0.88 SENP1 (0.38) HPGDMEN1KMT2ARXFP1MAPT
SCHEMBL479676 0.88 SENP1 (0.38) HPGDMEN1KMT2ARXFP1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7514468-B2 Indolinone derivatives substituted in the 6 position, the preparation thereof and their use as pharmaceutical compositions BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) 2009-04-07 — — US disclosed
US-20060194813-A1 Indolinone derivatives substituted in the 6 position, the preparation thereof and their use as pharmaceutical compositions BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) 2006-08-31 — — US disclosed
EP-1527046-A1 INDOLINE DERIVATIVES SUBSTITUTED IN POSITION 6, PRODUCTION AND USE THEREOF AS MEDICAMENTS BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) 2005-05-04 — — EP disclosed
WO-2004009546-A1 INDOLINE DERIVATIVES SUBSTITUTED IN POSITION 6, PRODUCTION AND USE THEREOF AS MEDICAMENTS BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) 2004-01-29 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060194813-A1 Indolinone derivatives substituted in the 6 position, the preparation thereof and their use as pharmaceutical compositions KDR, FLT1, EGFR HPGD 2420/4885TSHR 503/4885MEN1 1288/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.