Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 9/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.47 |
| ▸ | DRD4 | P21917 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 6/20 | 0.41 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.39 |
| ▸ | CCR3 | P51677 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 3/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3300158 | 0.90 | CHRM3 (0.56) | CHRM3ADRB2 | |
| SCHEMBL4487266 | 0.83 | ADRB2 (0.49) | CHRM3ADRB2DRD4DRD2CCR3 | |
| SCHEMBL5802413 | 0.81 | CD274 (0.37) | CHRM3ADRB2DRD4DRD2DRD3 | |
| SCHEMBL4484440 | 0.80 | CHRM3 (0.40) | CHRM3ADRB2 | |
| SCHEMBL4494456 | 0.80 | CHRM3 (0.38) | CHRM3ADRB2 | |
| SCHEMBL264728 | 0.79 | CHRM3 (0.63) | CHRM3ADRB2 | |
| SCHEMBL4475337 | 0.78 | CHRM3 (0.45) | CHRM3ADRB2SLC5A7HTR1A | |
| SCHEMBL4471210 | 0.77 | CCR3 (0.48) | CHRM3ADRB2DRD4DRD2SLC5A7 | |
| SCHEMBL4493974 | 0.76 | CHRM3 (0.38) | CHRM3ADRB2 | |
| SCHEMBL4474425 | 0.76 | CHRM3 (0.46) | CHRM3ADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632847-B2 | Bronchodilators; treating chronic obstructive pulmonary disease or asthma; long duration of action; reduced side effects, such as dry-mouth and constipation; e.g. biphenyl-2-ylcarbamic acid 1-(2-(3-[3-(4-hydroxybenzylamino)propionylamino]benzoylamino)ethyl)piperidin-4-yl ester | THERAVANCE, INC. (US) | 2009-12-15 | — | — | US | disclosed |