Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 7/20 | 0.50 |
| ▸ | OPRD1 | P41143 | 7/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 7/20 | 0.50 |
| ▸ | PDE4A | P27815 | 2/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.48 |
| ▸ | PDCD1 | Q15116 | 5/20 | 0.46 |
| ▸ | CD274 | Q9NZQ7 | 5/20 | 0.46 |
| ▸ | HTR1D | P28221 | 2/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | PLAT | P00750 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4480489 | 0.87 | OPRM1 (0.52) | OPRM1OPRD1OPRK1PDE4APDE4B | |
| SCHEMBL4074327 | 0.86 | OPRM1 (0.56) | OPRM1OPRD1OPRK1PDE4APDE4B | |
| SCHEMBL4084233 | 0.83 | OPRM1 (0.57) | OPRM1OPRD1OPRK1HTR1DHDAC1 | |
| SCHEMBL12607941 | 0.81 | OPRM1 (0.55) | OPRM1OPRD1OPRK1HDAC1 | |
| Hydrochloric Acid SCHEMBL3337917 | 0.80 | OPRM1 (0.55) | OPRM1OPRD1OPRK1HDAC1 | |
| SCHEMBL12608131 | 0.79 | KCNH2 (0.54) | OPRM1OPRD1OPRK1PDE4APDE4B | |
| SCHEMBL4075715 | 0.79 | HDAC1 (0.48) | OPRM1OPRD1OPRK1HTR1DHDAC1 | |
| Hydrochloric Acid SCHEMBL3343673 | 0.78 | KCNH2 (0.53) | OPRM1OPRD1OPRK1PDE4APDE4B | |
| SCHEMBL4478715 | 0.78 | OPRM1 (0.64) | OPRM1OPRD1OPRK1HDAC1 | |
| SCHEMBL4075949 | 0.78 | OPRM1 (0.57) | OPRM1OPRD1OPRK1PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7615651-B2 | Diaryl, dipyridinyl and aryl-pyridinyl derivatives and uses thereof | PFIZER INC. (US) | 2009-11-10 | — | — | US | claimed |