Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | TUBB1 | Q9H4B7 | 6/20 | 0.40 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | PTGES | O14684 | 1/20 | 0.35 |
| ▸ | TPMT | P51580 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.33 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12780330 | 0.84 | TUBB1 (0.43) | LMNAMAPK1HTTRAB9ATUBB1 | |
| SCHEMBL10838871 | 0.81 | TUBB1 (0.41) | LMNAMAPK1HTTRAB9ATUBB1 | |
| SCHEMBL1458628 | 0.77 | LMNA (0.58) | LMNAMAPK1HTTRAB9ATUBB1 | |
| SCHEMBL4457802 | 0.76 | SLC6A3 (0.53) | CES2CES1 | |
| SCHEMBL10762807 | 0.75 | CHRNA1 (0.57) | LMNAMAPK1HTTRAB9ACES2 | |
| SCHEMBL2125873 | 0.75 | PTGS2 (0.54) | LMNAAPPCYP2C19PTGS2AKR1C3 | |
| SCHEMBL20607111 | 0.74 | TUBB1 (0.39) | LMNAMAPK1HTTRAB9ATUBB1 | |
| SCHEMBL507133 | 0.74 | LMNA (0.50) | LMNAMAPK1HTTRAB9ATUBB1 | |
| SCHEMBL312536 | 0.72 | TUBB1 (0.45) | LMNAMAPK1HTTRAB9ATUBB1 | |
| SCHEMBL3144242 | 0.72 | TSHR (0.53) | LMNAMAPK1HTTRAB9ATUBB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632845-B2 | 2-(p-oxyphenyl)-6-oxyquinolines, e.g., 2-(3-Fluoro-4-hydroxyphenyl)-4-phenylquinolin-6-ol; inflammatory bowel disease; Crohn's disease; anticarcinogenic agents; anticholesterol agents; antilipemic agents; cardiovascular diorders; osteoporosis; A lzheimer's disease; fertility; antiarthritic agents | WYETH (US) | 2009-12-15 | — | — | US | disclosed |
| US-20060217399-A1 | Phenyl quinolines and their use as estrogenic agents | WYETH (US) | 2006-09-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060217399-A1 | Phenyl quinolines and their use as estrogenic agents | ESR1, GPER1, ESR2 | LMNA 3392/4885MAPK1 684/4885HTT 3857/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.