Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 9/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.45 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.45 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.45 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.45 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.45 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6995834 | 0.83 | RAPGEF4 (0.53) | RAPGEF4SIGMAR1MAPTGRIN2DGRIN3B | |
| SCHEMBL16590399 | 0.82 | RAPGEF4 (0.51) | RAPGEF4SIGMAR1MAPTGRIN2DGRIN3B | |
| SCHEMBL28200859 | 0.80 | RAPGEF4 (0.50) | RAPGEF4SIGMAR1MAPTGRIN2DGRIN3B | |
| SCHEMBL8896899 | 0.79 | RAPGEF4 (0.67) | RAPGEF4SIGMAR1MAPTGRIN2DGRIN3B | |
| SCHEMBL21969785 | 0.77 | RAPGEF4 (0.47) | RAPGEF4SIGMAR1MAPTGRIN2DGRIN3B | |
| SCHEMBL3617649 | 0.77 | RAPGEF4 (0.55) | RAPGEF4SIGMAR1MAPTGRIN2DGRIN3B | |
| SCHEMBL20984483 | 0.76 | GAA (0.61) | RAPGEF4SIGMAR1MAPTGRIN2DGRIN3B | |
| SCHEMBL28092014 | 0.76 | RAPGEF4 (0.46) | RAPGEF4SIGMAR1MAPTGRIN2DGRIN3B | |
| SCHEMBL28636989 | 0.76 | RAPGEF4 (0.46) | RAPGEF4SIGMAR1MAPTGRIN2DGRIN3B | |
| SCHEMBL28091889 | 0.76 | RAPGEF4 (0.46) | RAPGEF4SIGMAR1MAPTGRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7511057-B2 | Triazolopyridinylsulfanyl derivatives as p38 MAP kinase inhibitors | PFIZER INC. (US) | 2009-03-31 | — | — | US | disclosed |
| US-20060035922-A1 | Triazolopyridinylsulfanyl derivatives as p38 MAP kinase inhibitors | PFIZER INC. | 2006-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060035922-A1 | Triazolopyridinylsulfanyl derivatives as p38 MAP kinase inhibitors | MAPK1, MAPKAPK5, MAPKAPK3 | RAPGEF4 1372/4885SIGMAR1 1869/4885MAPT 737/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.