Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 9/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.47 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.47 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.47 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.47 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.47 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4487877 | 0.83 | RAPGEF4 (0.50) | RAPGEF4SIGMAR1MAPTGRIN2DGRIN3B | |
| SCHEMBL8849827 | 0.82 | CALM1 (0.38) | RAPGEF4MAPTGAA | |
| SCHEMBL8896899 | 0.82 | RAPGEF4 (0.67) | RAPGEF4SIGMAR1MAPTGRIN2DGRIN3B | |
| SCHEMBL3617649 | 0.80 | RAPGEF4 (0.55) | RAPGEF4SIGMAR1MAPTGRIN2DGRIN3B | |
| SCHEMBL11918975 | 0.78 | RAPGEF4 (0.53) | RAPGEF4SIGMAR1MAPTGRIN2DGRIN3B | |
| Hydrochloric Acid SCHEMBL2868312 | 0.78 | RAPGEF4 (0.53) | RAPGEF4SIGMAR1MAPTGRIN2DGRIN3B | |
| SCHEMBL11421191 | 0.78 | HDAC4 (0.54) | RAPGEF4SIGMAR1MAPTGRIN2DGRIN3B | |
| SCHEMBL5144284 | 0.78 | RAPGEF4 (0.53) | RAPGEF4SIGMAR1MAPTGRIN2DGRIN3B | |
| SCHEMBL30012057 | 0.78 | RAPGEF4 (0.53) | RAPGEF4SIGMAR1MAPTGRIN2DGRIN3B | |
| SCHEMBL28049042 | 0.78 | RAPGEF4 (0.53) | RAPGEF4SIGMAR1MAPTGRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1292579-A1 | SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL PYRAZINONES USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE | Pharmacia Corporation (US) | 2003-03-19 | — | — | EP | claimed |
| WO-2001087854-A1 | SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL PYRAZINONES USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE | PHARMACIA CORPORATION (US) | 2001-11-22 | — | — | WO | claimed |
| CN-101671301-B | Heterocyclic substituent acardite derivate and application thereof | JIANGSU PROVINCIAL INST OF MATERIA MEDICA CO LTD | 2014-02-26 | — | — | CN | disclosed |
| CN-101663305-A | 2-amino-5, 7-dihydro-6H-pyrrolo [3, 4-D ] pyrimidine derivatives as HSP-90 inhibitors for the treatment of cancer | PFIZER | 2010-03-03 | — | — | CN | disclosed |