Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | FPR2 | P25090 | 7/20 | 0.33 |
| ▸ | FPR1 | P21462 | 5/20 | 0.33 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.31 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.31 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | MET | P08581 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3986813 | 0.86 | TRAP1 (0.37) | MAPTKDM4ENPC1USP2RECQL | |
| SCHEMBL4486345 | 0.86 | TRAP1 (0.37) | MAPTKDM4ENPC1USP2RECQL | |
| SCHEMBL4485590 | 0.78 | TP53 (0.33) | MAPTKMT2ATP53POLBSMN1; SMN2 | |
| SCHEMBL3993899 | 0.78 | TP53 (0.33) | MAPTKMT2ATP53POLBSMN1; SMN2 | |
| SCHEMBL4487540 | 0.70 | FPR1 (0.33) | FPR2FPR1 | |
| SCHEMBL3985848 | 0.70 | FPR1 (0.34) | FPR2FPR1 | |
| SCHEMBL4489281 | 0.69 | KCNH2 (0.34) | SMN1; SMN2 | |
| SCHEMBL4482238 | 0.67 | LYN (0.32) | MAPT | |
| SCHEMBL4481630 | 0.67 | ACLY (0.31) | — | |
| SCHEMBL4492304 | 0.67 | ACLY (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090186907-A1 | Pyrazinones As Cellular Proliferation Inhibitors | E.I. DUPONT DE NEMOURS AND COMPANY (US) | 2009-07-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090186907-A1 | Pyrazinones As Cellular Proliferation Inhibitors | MKI67, NR0B1, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | MAPT 4590/4885KDM4E 3719/4885NPC1 698/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.