Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.52 |
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4490770 | 0.92 | KMT2A (0.54) | KMT2ARAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL4481521 | 0.90 | NPC1 (0.56) | KMT2ARAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL12886394 | 0.88 | HDAC6 (0.50) | KMT2ARAB9ASMN1; SMN2NPC1CYP1A2 | |
| SCHEMBL4491049 | 0.87 | SMN1; SMN2 (0.64) | KMT2ARAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL4490556 | 0.85 | GSK3B (0.54) | KMT2ARAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL12886382 | 0.85 | AAK1 (0.58) | KMT2A | |
| SCHEMBL4491703 | 0.84 | ALDH1A1 (0.55) | KMT2ARAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL4490154 | 0.83 | MEN1 (0.50) | KMT2AMEN1 | |
| SCHEMBL4498152 | 0.82 | GSK3B (0.52) | CYP1A2 | |
| SCHEMBL4502574 | 0.82 | GSK3B (0.57) | CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |