Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.58 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4481521 | 0.93 | NPC1 (0.56) | SMN1; SMN2ALDH1A1RCE1HDAC1HDAC2 | |
| SCHEMBL4490770 | 0.91 | KMT2A (0.54) | SMN1; SMN2ALDH1A1CYP1A2CYP2C19HSD17B10 | |
| SCHEMBL4491703 | 0.87 | ALDH1A1 (0.55) | SMN1; SMN2ALDH1A1RCE1HDAC1HDAC2 | |
| SCHEMBL4490101 | 0.87 | KMT2A (0.52) | SMN1; SMN2ALDH1A1CYP1A2CYP2C19NPC1 | |
| SCHEMBL4490556 | 0.85 | GSK3B (0.54) | SMN1; SMN2ALDH1A1HDAC1HDAC2HDAC8 | |
| SCHEMBL12886394 | 0.83 | HDAC6 (0.50) | SMN1; SMN2CYP1A2NPC1HDAC6KMT2A | |
| SCHEMBL4486921 | 0.83 | HDAC6 (0.55) | HDAC1HDAC2HDAC8HDAC6KDM4E | |
| SCHEMBL4476091 | 0.82 | HDAC1 (0.52) | HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL4502964 | 0.82 | HDAC1 (0.63) | HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL4489897 | 0.82 | HDAC1 (0.63) | HDAC1HDAC2HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |