Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 8/20 | 0.53 |
| ▸ | HTR3B | O95264 | 8/20 | 0.53 |
| ▸ | HTR3A | P46098 | 8/20 | 0.53 |
| ▸ | HTR3D | Q70Z44 | 8/20 | 0.53 |
| ▸ | HTR3C | Q8WXA8 | 8/20 | 0.53 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.49 |
| ▸ | ITGAV | P06756 | 2/20 | 0.49 |
| ▸ | SLC22A2 | O15244 | 3/20 | 0.47 |
| ▸ | SLC22A1 | O15245 | 3/20 | 0.47 |
| ▸ | SLC22A3 | O75751 | 3/20 | 0.47 |
| ▸ | PLAU | P00749 | 3/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | ATP4A | P20648 | 3/20 | 0.38 |
| ▸ | ATP4B | P51164 | 3/20 | 0.38 |
| ▸ | MPO | P05164 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.37 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1116487 | 0.80 | ITGB3 (0.37) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL11881011 | 0.79 | SLC22A2 (0.50) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL4480691 | 0.79 | ITGB3 (0.72) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL11882912 | 0.76 | SLC22A2 (0.47) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL11878422 | 0.76 | HTR3E (0.53) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL11879687 | 0.76 | HTR3E (0.53) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL11881250 | 0.76 | HTR3E (0.53) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL11883015 | 0.76 | PLAU (0.47) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL11878842 | 0.76 | SLC22A2 (0.47) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL11879676 | 0.76 | PLAU (0.53) | HTR3EHTR3BHTR3AHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7501415-B2 | Selective inhibitors of ERK protein kinase and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-03-10 | — | — | US | disclosed |
| EP-1833820-A1 | SELECTIVE INHIBITORS OF ERK PROTEIN KINASE AND USES THEROF | Vertex Pharmaceuticals Incorporated (US) | 2007-09-19 | — | — | EP | disclosed |
| US-20060160807-A1 | Selective inhibitors of ERK protein kinase and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED | 2006-07-20 | — | — | US | disclosed |
| WO-2006071644-A1 | SELECTIVE INHIBITORS OF ERK PROTEIN KINASES AND USES THEROF | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2006-07-06 | — | — | WO | disclosed |
| US-3976643-A | FROM AN ANILINE AND CYANAMIDE | WILLIAM H. RORER, INC. (US) | 1976-08-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060160807-A1 | Selective inhibitors of ERK protein kinase and uses thereof | MAP3K20, MAP4K2, MAP4K1 | HTR3E 3968/4885HTR3B 4072/4885HTR3A 4436/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.