Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | PSEN1 | P49768 | 7/20 | 0.46 |
| ▸ | PSEN2 | P49810 | 7/20 | 0.46 |
| ▸ | APH1B | Q8WW43 | 7/20 | 0.46 |
| ▸ | NCSTN | Q92542 | 7/20 | 0.46 |
| ▸ | APH1A | Q96BI3 | 7/20 | 0.46 |
| ▸ | PSENEN | Q9NZ42 | 7/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 2/20 | 0.41 |
| ▸ | HTR7 | P34969 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | MMP12 | P39900 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4491616 | 1.00 | KMT2A (0.54) | KMT2AALDH1A1GAAHPGDHTT | |
| SCHEMBL1913203 | 0.82 | REN (0.65) | KMT2AALDH1A1GAAHPGDHTT | |
| SCHEMBL4514580 | 0.78 | REN (0.53) | ALDH1A1HTTTSHRL3MBTL1MMP8 | |
| SCHEMBL4514576 | 0.78 | REN (0.53) | ALDH1A1HTTTSHRL3MBTL1MMP8 | |
| SCHEMBL22089497 | 0.78 | ALDH1A1 (0.47) | KMT2AALDH1A1GAAHPGDHTT | |
| SCHEMBL4504905 | 0.77 | ALDH1A1 (0.56) | ALDH1A1L3MBTL1HTR1AHTR7REN | |
| SCHEMBL4504903 | 0.77 | ALDH1A1 (0.56) | ALDH1A1L3MBTL1HTR1AHTR7REN | |
| SCHEMBL4508093 | 0.76 | REN (0.59) | ALDH1A1TSHRREN | |
| SCHEMBL4508089 | 0.76 | REN (0.59) | ALDH1A1TSHRREN | |
| SCHEMBL4502902 | 0.75 | REN (0.45) | ALDH1A1TSHRMAPTREN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090233920-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2009-09-17 | — | — | US | claimed |
| EP-1907359-A2 | 3,5-SUBSTITUTED PIPERIDINE DERIVATIVES EFFECTIVE ON RENIN-RELATED DISORDERS | Novartis AG (CH) | 2008-04-09 | — | — | EP | claimed |
| WO-2007006534-A2 | PIPERIDINE DERIVATIVES USEFUL IN THE DIAGNOSTIC AND THERAPEUTIC TREATMENT OF DISEASES DEPENDING ON RENIN ACTIVITY | NOVARTIS AG (CH) | 2007-01-18 | — | — | WO | claimed |
| US-20090233920-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2009-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233920-A1 | ORGANIC COMPOUNDS | REN, ACE, AGTR1 | KMT2A 3192/4885ALDH1A1 39/4885GAA 353/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.