Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 15/20 | 0.68 |
| ▸ | CDK2 | P24941 | 1/20 | 0.68 |
| ▸ | GSK3A | P49840 | 1/20 | 0.68 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4479144 | 0.86 | GSK3B (0.71) | GSK3BGSK3AHDAC1HDAC2CYP1A2 | |
| SCHEMBL4483353 | 0.86 | GSK3B (0.70) | GSK3BCDK2GSK3ACYP1A2 | |
| SCHEMBL4491491 | 0.84 | GSK3B (0.73) | GSK3BCDK2GSK3AHDAC1HDAC2 | |
| SCHEMBL4502378 | 0.84 | GSK3A (0.92) | GSK3BCDK2GSK3AHDAC1HDAC2 | |
| SCHEMBL4503133 | 0.83 | GSK3B (0.70) | GSK3BCDK2GSK3AHDAC1HDAC2 | |
| SCHEMBL4487872 | 0.83 | GSK3B (0.71) | GSK3BCDK2GSK3AHDAC1HDAC2 | |
| SCHEMBL4500329 | 0.82 | GSK3B (0.68) | GSK3BGSK3AHDAC1HDAC2CYP1A2 | |
| SCHEMBL4486136 | 0.82 | GSK3B (0.54) | GSK3BHDAC1HDAC2CYP1A2HDAC8 | |
| SCHEMBL4500078 | 0.82 | GSK3B (0.57) | GSK3BCYP1A2 | |
| SCHEMBL4497780 | 0.82 | GSK3B (0.60) | GSK3BCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |