Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 6/20 | 0.62 |
| ▸ | AKR1C3 | P42330 | 7/20 | 0.57 |
| ▸ | AKR1C2 | P52895 | 7/20 | 0.57 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.53 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.53 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.53 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.53 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.53 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.53 |
| ▸ | FABP2 | P12104 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4498010 | 0.87 | APP (0.62) | APPAKR1C3AKR1C2PTGS1CYP2C19 | |
| SCHEMBL6689605 | 0.85 | AKR1C3 (0.78) | APPAKR1C3AKR1C2PTGS1CYP2C19 | |
| SCHEMBL4514080 | 0.83 | EPHX1 (0.47) | APPPTGS2 | |
| SCHEMBL4499429 | 0.83 | EPHX1 (0.47) | APPPTGS2 | |
| SCHEMBL5319051 | 0.82 | LMNA (0.78) | APPAKR1C3AKR1C2PTGS1CYP2C19 | |
| SCHEMBL2357848 | 0.82 | LMNA (0.78) | APPAKR1C3AKR1C2PTGS1CYP2C19 | |
| SCHEMBL4494820 | 0.81 | APP (0.56) | APPAKR1C3AKR1C2PTGS1CYP2C19 | |
| SCHEMBL4505580 | 0.75 | APP (0.55) | APPAKR1C3AKR1C2CYP2C19CYP2C9 | |
| SCHEMBL1372793 | 0.73 | AKR1C3 (1.00) | APPAKR1C3AKR1C2PTGS1CYP2C19 | |
| SCHEMBL2357849 | 0.73 | NPSR1 (0.54) | APPAKR1C3AKR1C2PTGS1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090291988-A1 | Reversible Inhibitors of Monoamine Oxidase A and B | MERCK FROSST CANADA LTD. (CA) | 2009-11-26 | — | — | US | claimed |
| US-20090291988-A1 | Reversible Inhibitors of Monoamine Oxidase A and B | MERCK FROSST CANADA LTD. (CA) | 2009-11-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090291988-A1 | Reversible Inhibitors of Monoamine Oxidase A and B | MAOB, MAOA, XDH | APP 1024/4885AKR1C3 306/4885AKR1C2 419/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.