Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 9/20 | 0.36 |
| ▸ | LDHB | P07195 | 8/20 | 0.36 |
| ▸ | ALB | P02768 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4488655 | 0.79 | KDM4E (0.36) | KDM4EMEN1ALDH1A1KMT2AUSP2 | |
| SCHEMBL4487481 | 0.78 | TLR8 (0.35) | LDHALDHBALDH1A1NPC1LMNA | |
| SCHEMBL4491011 | 0.76 | SMN1; SMN2 (0.44) | LDHALDHBKDM4EMEN1ALDH1A1 | |
| SCHEMBL4491755 | 0.73 | TRPV1 (0.36) | LDHALDHBKDM4EMEN1ALDH1A1 | |
| SCHEMBL4498684 | 0.73 | CSNK1D (0.44) | CDK2 | |
| SCHEMBL4496742 | 0.72 | CCR1 (0.36) | LDHALDHBALBALDH1A1NPC1 | |
| SCHEMBL4504198 | 0.71 | LDHA (0.38) | LDHALDHBALBKDM4EMEN1 | |
| SCHEMBL4492061 | 0.70 | ALDH1A1 (0.40) | MEN1ALDH1A1KMT2APOLBLMNA | |
| SCHEMBL4491747 | 0.69 | MEN1 (0.40) | MEN1ALDH1A1KMT2APOLBGAA | |
| SCHEMBL4492959 | 0.69 | CA12 (0.41) | KDM4EMEN1ALDH1A1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504429-B2 | Tyrosine kinase inhibitors | MERCK & CO., INC. (US) | 2009-03-17 | — | — | US | claimed |