Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1D | P48730 | 2/20 | 0.44 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.44 |
| ▸ | CLK2 | P49760 | 1/20 | 0.44 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.44 |
| ▸ | CDC7 | O00311 | 3/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.34 |
| ▸ | GCGR | P47871 | 2/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.34 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4491011 | 0.87 | SMN1; SMN2 (0.44) | — | |
| SCHEMBL4485668 | 0.83 | ALDH1A1 (0.39) | CSNK1DCSNK1A1CLK2CSNK1G1CDC7 | |
| SCHEMBL4491747 | 0.80 | MEN1 (0.40) | CDC7 | |
| SCHEMBL4495480 | 0.80 | ALDH1A1 (0.42) | TLR9TLR8TLR7KDM5B | |
| SCHEMBL4504198 | 0.79 | LDHA (0.38) | TLR9TLR8TLR7KDM5B | |
| SCHEMBL7694078 | 0.78 | CSNK1A1 (0.66) | CSNK1DCSNK1A1CLK2CSNK1G1CDC7 | |
| SCHEMBL4488655 | 0.76 | KDM4E (0.36) | KDM5B | |
| SCHEMBL7685201 | 0.76 | CSNK1A1 (0.72) | CSNK1DCSNK1A1CLK2CSNK1G1CDC7 | |
| SCHEMBL4491755 | 0.76 | TRPV1 (0.36) | — | |
| SCHEMBL4487481 | 0.75 | TLR8 (0.35) | TLR9TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504429-B2 | Tyrosine kinase inhibitors | MERCK & CO., INC. (US) | 2009-03-17 | — | — | US | claimed |