Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 18/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.57 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.57 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.46 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.46 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.44 |
| ▸ | TUBB | P07437 | 1/20 | 0.44 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.44 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.44 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.44 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.44 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.44 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL447722 | 0.93 | HDAC1 (0.59) | HDAC1HDAC3HDAC2HDAC4HDAC7 | |
| SCHEMBL446646 | 0.91 | HDAC1 (0.56) | HDAC1HDAC3HDAC2HDAC4HDAC7 | |
| SCHEMBL449407 | 0.91 | HDAC1 (0.56) | HDAC1HDAC3HDAC2HDAC4HDAC7 | |
| SCHEMBL452316 | 0.89 | HDAC1 (0.55) | HDAC1HDAC3HDAC2HDAC4HDAC7 | |
| SCHEMBL447230 | 0.88 | HDAC1 (0.54) | HDAC1HDAC3HDAC2HDAC4HDAC7 | |
| SCHEMBL448060 | 0.88 | HDAC1 (0.53) | HDAC1HDAC3HDAC2HDAC4HDAC7 | |
| SCHEMBL449975 | 0.86 | HDAC1 (0.61) | HDAC1HDAC3HDAC2HDAC4HDAC7 | |
| SCHEMBL450368 | 0.85 | HDAC1 (0.61) | HDAC1HDAC3HDAC2HDAC4HDAC7 | |
| SCHEMBL450287 | 0.83 | HDAC1 (0.67) | HDAC1HDAC3HDAC2HDAC4HDAC7 | |
| SCHEMBL449565 | 0.81 | HDAC1 (0.56) | HDAC1HDAC3HDAC2HDAC4HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8716326-B2 | Isoindolinone derivatives, preparation method thereof and a pharmaceutical composition comprising same | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2014-05-06 | — | — | US | claimed |
| EP-2429987-A2 | AMIDE COMPOUND, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING SAME | Korea Research Institute Of Chemical Technology (KR) | 2012-03-21 | — | — | EP | claimed |
| US-20120065396-A1 | ISOINDOLINONE DERIVATIVES, PREPARATION METHOD THEREOF AND A PHARMACEUTICAL COMPOSITION COMPRISING SAME | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2012-03-15 | — | — | US | claimed |
| WO-2010131922-A2 | AMIDE COMPOUND, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING SAME | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2010-11-18 | — | — | WO | claimed |
| US-9850353-B2 | Articles and armor materials incorporating fiber-free compositions and methods of forming same | ORBITAL ATK, INC. (US) | 2017-12-26 | — | — | US | disclosed |
| US-20150361229-A1 | ARTICLES AND ARMOR MATERIALS INCORPORATING FIBER-FREE COMPOSITIONS AND METHODS OF FORMING SAME | NORTHROP GRUMMAN SYSTEMS CORPORATION | 2015-12-17 | — | — | US | disclosed |
| US-8716326-B2 | Isoindolinone derivatives, preparation method thereof and a pharmaceutical composition comprising same | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2014-05-06 | — | — | US | disclosed |
| EP-2429987-A2 | AMIDE COMPOUND, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING SAME | Korea Research Institute Of Chemical Technology (KR) | 2012-03-21 | — | — | EP | disclosed |
| US-20120065294-A1 | INSULATIVE COMPOSITIONS, ARTICLE INCORPORATING THE SAME AND METHODS OF FORMING THE SAME | ALLIANT TECHSYSTEMS INC. (US) | 2012-03-15 | — | — | US | disclosed |
| US-20120065396-A1 | ISOINDOLINONE DERIVATIVES, PREPARATION METHOD THEREOF AND A PHARMACEUTICAL COMPOSITION COMPRISING SAME | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2012-03-15 | — | — | US | disclosed |
| WO-2010131922-A2 | AMIDE COMPOUND, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING SAME | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2010-11-18 | — | — | WO | disclosed |
| EP-1373386-B1 | FIBER-REINFORCED ROCKET MOTOR INSULATION | ALLIANT TECHSYSTEMS INC (US) | 2006-08-16 | — | — | EP | disclosed |
| US-7070705-B2 | Fiber-reinforced rocket motor insulation | ALLIANT TECHSYSTEMS INC. (US) | 2006-07-04 | — | — | US | disclosed |
| US-20040157979-A1 | Fiber-reinforced rocket motor insulation | NORTHROP GRUMMAN SYSTEMS CORPORATION | 2004-08-12 | — | — | US | disclosed |
| WO-2002079307-A9 | FIBER-REINFORCED ROCKET MOTOR INSULATION | ALLIANT TECHSYSTEMS INC (US) | 2004-05-06 | — | — | WO | disclosed |
| US-6691505-B2 | Fiber-reinforced rocket motor insulation | ALLIANT TECHSYSTEMS INC. | 2004-02-17 | — | — | US | disclosed |
| EP-1373386-A2 | FIBER-REINFORCED ROCKET MOTOR INSULATION | Alliant Techsystems Inc. (US) | 2004-01-02 | — | — | EP | disclosed |
| US-20020189233-A1 | Fiber-reinforced rocket motor insulation | NORTHROP GRUMMAN SYSTEMS CORPORATION | 2002-12-19 | — | — | US | disclosed |
| WO-2002079307-A2 | FIBER-REINFORCED ROCKET MOTOR INSULATION | ALLIANT TECHSYSTEMS INC. (US) | 2002-10-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120065396-A1 | ISOINDOLINONE DERIVATIVES, PREPARATION METHOD THEREOF AND A PHARMACEUTICAL COMPOSITION COMPRISING SAME | PPIP5K2, SOST, ALPL | HDAC1 761/4885HDAC3 638/4885HDAC2 641/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.