Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4495219 | 0.81 | CYP2D6 (0.42) | ALDH1A1KMT2AGAAMEN1LMNA | |
| SCHEMBL4486069 | 0.80 | ALDH1A1 (0.57) | SIRT6ALDH1A1HPGDKMT2AGAA | |
| SCHEMBL4490094 | 0.80 | ALDH1A1 (0.50) | SIRT6ALDH1A1HPGDKMT2AGAA | |
| SCHEMBL1361808 | 0.76 | ALDH1A1 (0.50) | SIRT6ALDH1A1HPGDKMT2AGAA | |
| SCHEMBL28411789 | 0.75 | ALDH1A1 (0.52) | SIRT6ALDH1A1HPGDKMT2AGAA | |
| SCHEMBL4493112 | 0.72 | CHRM3 (0.53) | SIRT6ALDH1A1HPGDKMT2AGAA | |
| SCHEMBL11002701 | 0.71 | ALDH1A1 (0.55) | ALDH1A1KMT2AGAAMEN1SMN1; SMN2 | |
| SCHEMBL17147663 | 0.71 | ALDH1A1 (0.47) | SIRT6ALDH1A1HPGDKMT2AGAA | |
| SCHEMBL1532324 | 0.70 | ALDH1A1 (0.58) | ALDH1A1KMT2AGAAMEN1SMN1; SMN2 | |
| SCHEMBL2103568 | 0.70 | MAPK1 (0.55) | ALDH1A1KMT2AGAAMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7514468-B2 | Indolinone derivatives substituted in the 6 position, the preparation thereof and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2009-04-07 | — | — | US | disclosed |