Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.44 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.44 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.44 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.44 |
| ▸ | MELK | Q14680 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17147663 | 0.91 | ALDH1A1 (0.47) | ALDH1A1HPGDKMT2ASIRT6SIGMAR1 | |
| SCHEMBL17147662 | 0.91 | DRD4 (0.44) | ALDH1A1HPGDKMT2ASIGMAR1DRD4 | |
| SCHEMBL3157089 | 0.89 | LMNA (0.56) | ALDH1A1KMT2ASIGMAR1DRD4MEN1 | |
| SCHEMBL28411789 | 0.88 | ALDH1A1 (0.52) | ALDH1A1HPGDKMT2ASIRT6SIGMAR1 | |
| SCHEMBL13808932 | 0.88 | DRD4 (0.47) | ALDH1A1DRD4HTTLMNACHEK1 | |
| SCHEMBL3143293 | 0.88 | LMNA (0.54) | ALDH1A1KMT2ASIGMAR1MEN1LMNA | |
| SCHEMBL3151719 | 0.86 | KMT2A (0.59) | ALDH1A1KMT2AMEN1KCNJ1LMNA | |
| SCHEMBL3157355 | 0.84 | DRD4 (0.65) | ALDH1A1SIGMAR1DRD4LMNAMAPK1 | |
| SCHEMBL7346358 | 0.84 | ALDH1A1 (0.62) | ALDH1A1HPGDKMT2ASIRT6MEN1 | |
| SCHEMBL27959322 | 0.83 | CHRM2 (0.47) | ALDH1A1HPGDKMT2ASIRT6SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115181078-B | Synthesis method of Nidamib key intermediate | 安徽修一制药有限公司 | 2024-07-19 | — | — | CN | claimed |
| CN-115181078-A | Synthesis method of nintedanib key intermediate | 安徽修一制药有限公司 | 2022-10-14 | — | — | CN | claimed |
| EP-4622986-A1 | BORONIC ACID AND BORONATE COMPOSITIONS AND METHODS | Elima Therapeutics, Inc. (US) | 2025-10-01 | — | — | EP | disclosed |
| CN-115181078-B | Synthesis method of Nidamib key intermediate | 安徽修一制药有限公司 | 2024-07-19 | — | — | CN | disclosed |
| CN-115181078-B | Synthesis method of Nidamib key intermediate | 安徽修一制药有限公司 | 2024-07-19 | — | — | CN | disclosed |
| WO-2024112705-A1 | BORONIC ACID AND BORONATE COMPOSITIONS AND METHODS | ELIMA THERAPEUTICS, INC. (US) | 2024-05-30 | — | — | WO | disclosed |
| CN-115181078-A | Synthesis method of nintedanib key intermediate | 安徽修一制药有限公司 | 2022-10-14 | — | — | CN | disclosed |
| CN-115181078-A | Synthesis method of nintedanib key intermediate | 安徽修一制药有限公司 | 2022-10-14 | — | — | CN | disclosed |
| CN-113354599-B | Preparation method of nintedanib key intermediate | 长沙康鹏医药有限公司 | 2021-10-26 | — | — | CN | disclosed |
| CN-113354599-A | Preparation method of nintedanib key intermediate | 长沙康鹏医药有限公司 | 2021-09-07 | — | — | CN | disclosed |
| EP-2229360-B1 | INDOLINONE DERIVATIVES AND PROCESS FOR THEIR MANUFACTURE | BOEHRINGER INGELHEIM INT (DE) | 2020-07-01 | — | — | EP | disclosed |
| CN-101883755-A | Indolinone derivatives and process for their manufacture | BOEHRINGER INGELHEIM INT | 2010-11-10 | — | — | CN | disclosed |
| CN-101883756-A | Process for preparing indolinone derivatives | BOEHRINGER INGELHEIM INT | 2010-11-10 | — | — | CN | disclosed |
| EP-2229359-A1 | PROCESS FOR THE MANUFACTURE OF AN INDOLINONE DERIVATIVE | Boehringer Ingelheim International GmbH (DE) | 2010-09-22 | — | — | EP | disclosed |
| EP-2157081-A1 | Indolinones substituted in six locations, their manufacture and their application as medicine | Boehringer Ingelheim Pharma GmbH & Co. KG (DE) | 2010-02-24 | — | — | EP | disclosed |
| EP-1224170-B1 | 6-POSITION SUBSTITUTED INDOLINE, PRODUCTION AND USE THEREOF AS A MEDICAMENT | BOEHRINGER INGELHEIM PHARMA (DE) | 2009-08-12 | — | — | EP | disclosed |
| WO-2009071523-A1 | PROCESS FOR THE MANUFACTURE OF AN INDOLINONE DERIVATIVE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-06-11 | — | — | WO | disclosed |
| US-6762180-B1 | Substituted indolines which inhibit receptor tyrosine kinases | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2004-07-13 | — | — | US | disclosed |
| EP-1224170-A1 | 6-POSITION SUBSTITUTED INDOLINE, PRODUCTION AND USE THEREOF AS A MEDICAMENT | Boehringer Ingelheim Pharma KG (DE) | 2002-07-24 | — | — | EP | disclosed |
| WO-2001027081-A1 | 6-POSITION SUBSTITUTED INDOLINE, PRODUCTION AND USE THEREOF AS A MEDICAMENT | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-04-19 | — | — | WO | disclosed |