Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1361808 | 0.91 | ALDH1A1 (0.50) | ALDH1A1KMT2ASIRT6HPGDHTT | |
| SCHEMBL17147662 | 0.88 | DRD4 (0.44) | ALDH1A1KMT2AHPGDSIGMAR1KCNJ1 | |
| SCHEMBL17147661 | 0.87 | KCNJ1 (0.48) | ALDH1A1KMT2ASIRT6SIGMAR1KCNJ1 | |
| SCHEMBL17147660 | 0.82 | ALDH1A1 (0.56) | ALDH1A1KMT2AHPGDLMNAMEN1 | |
| SCHEMBL3157089 | 0.81 | LMNA (0.56) | ALDH1A1KMT2ASIGMAR1LMNAMEN1 | |
| SCHEMBL7346358 | 0.81 | ALDH1A1 (0.62) | ALDH1A1KMT2ASIRT6HPGDHTT | |
| SCHEMBL28411789 | 0.80 | ALDH1A1 (0.52) | ALDH1A1KMT2ASIRT6HPGDHTT | |
| SCHEMBL3143293 | 0.80 | LMNA (0.54) | ALDH1A1KMT2ASIGMAR1LMNAMEN1 | |
| SCHEMBL13808932 | 0.80 | DRD4 (0.47) | ALDH1A1HTTLMNASMN1; SMN2KDM4E | |
| SCHEMBL27959322 | 0.80 | CHRM2 (0.47) | ALDH1A1KMT2ASIRT6HPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160257648-A1 | OXINDOLE INHIBITORS OF TYROSINE KINASE | AUSPEX PHARMACEUTICALS, INC. | 2016-09-08 | — | — | US | disclosed |
| US-20150284327-A1 | OXINDOLE INHIBITORS OF TYROSINE KINASE | AUSPEX PHARMACEUTICALS, INC. (US) | 2015-10-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150284327-A1 | OXINDOLE INHIBITORS OF TYROSINE KINASE | ABL1, ERBB2, LCK | ALDH1A1 2361/4885KMT2A 1089/4885SIRT6 3789/4885 |
| US-20160257648-A1 | OXINDOLE INHIBITORS OF TYROSINE KINASE | ABL1, ERBB2, LCK | ALDH1A1 2361/4885KMT2A 1089/4885SIRT6 3789/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.