Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.37 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | UBE2M | P61081 | 1/20 | 0.36 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3223567 | 0.90 | LSS (0.41) | LSSALDH1A1POLBTSHRKMT2A | |
| SCHEMBL4492293 | 0.87 | ALDH1A1 (0.37) | ALDH1A1POLBTSHRKMT2AKDM4E | |
| SCHEMBL4475964 | 0.87 | ALDH1A1 (0.42) | ALDH1A1POLBTSHRKMT2AKDM4E | |
| SCHEMBL4811916 | 0.84 | ALDH1A1 (0.47) | ALDH1A1POLBTSHRKMT2AEGLN2 | |
| SCHEMBL1477715 | 0.83 | LSS (0.40) | LSSCXCR1KDRKDM4EHRH3 | |
| SCHEMBL4488294 | 0.83 | ALDH1A1 (0.34) | ALDH1A1POLBTSHRKMT2AEGLN2 | |
| SCHEMBL973763 | 0.80 | ALDH1A1 (0.43) | ALDH1A1POLBTSHRKMT2AUBE2M | |
| SCHEMBL7165653 | 0.78 | ALDH1A1 (0.42) | ALDH1A1POLBTSHRKMT2AEGLN2 | |
| SCHEMBL4488290 | 0.78 | PDE2A (0.35) | EGLN2HRH3 | |
| SCHEMBL4494835 | 0.78 | PDE2A (0.35) | EGLN2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7507739-B2 | 6-[(substituted)phenyl]triazolopyrimidines as anticancer agents | WYETH (US) | 2009-03-24 | — | — | US | disclosed |
| EP-1680425-B1 | 6- [(SUBSTITUTED)PHENYL] TRIAZOLOPYRIMIDINES AS ANTICANCER AGENTS | WYETH CORP (US) | 2007-01-10 | — | — | EP | disclosed |